良性病变腹腔镜子宫全切术后围绝经期症状的影响因素分析  

Analysis of influencing factors of perimenopausal symptoms after laparoscopic total hysterectomy for benign uterine lesions

作　　者：窦舒兰 丁玲 施如霞 DOU Shulan;DING Ling;SHI Ruxia(Department of Gynecology,Changzhou Second People’s Hospital Affiliated to Nanjing Medical University,Jiangsu Province,Changzhou 213000,China)

机构地区：[1]南京医科大学附属常州第二人民医院妇科,江苏常州213000

出　　处：《中国医药导报》2022年第6期102-105,134,共5页China Medical Herald

基　　金：江苏省研究生实践创新计划项目(SJCX180860)。

摘　　要：目的分析良性病变腹腔镜子宫全切术后围绝经期症状的影响因素。方法回顾性分析2018年3月至2020年3月南京医科大学附属常州第二人民医院收治的79例因子宫良性病变行腹腔镜子宫全切术的围绝经期患者的临床资料。分别于术前、术后1个月、术后1年测定患者性激素水平,采用改良Kupperman评分量表评定围绝经期症状,统计良性病变腹腔镜子宫全切术患者术后1年围绝经期症状的发生情况,分析影响良性病变腹腔镜子宫全切术后患者发生围绝经期症状的因素。结果79例患者随访1年,丢失1例患者,不计入统计。术后1年,良性病变腹腔镜子宫全切术患者雌二醇、孕酮、睾酮水平低于术后1个月、术前,卵泡刺激素、促黄体生成素水平高于术后1个月、术前,差异有统计学意义(P<0.05);术后1个月,良性病变腹腔镜子宫全切术患者雌二醇、孕酮、睾酮水平低于术前,卵泡刺激素、促黄体生成素水平高于术前,差异有统计学意义(P<0.05)。术后1年共有31例发生围绝经期症状,发生率为39.74%。发生与未发生围绝经期症状患者绝经及术后1个月雌二醇、孕酮、卵泡刺激素、促黄体生成素、睾酮水平比较,差异有统计学意义(P<0.05)。绝经及雌二醇、孕酮、睾酮水平是影响良性病变腹腔镜子宫全切术后患者发生围绝经期症状的独立危险因素(OR>1,P<0.05)。结论良性病变腹腔镜子宫全切术患者术后血清雌二醇、孕酮、睾酮水平异常降低,卵泡刺激素、促黄体生成素水平异常升高,且该类患者易发生围绝经期症状。血清雌二醇、睾酮、孕酮水平是良性病变腹腔镜子宫全切术患者发生围绝经期症状的独立危险因素。Objective To analyze the influencing factors of perimenopausal symptoms after laparoscopic hysterectomy for benign uterine lesions.Methods A retrospective analysis was performed on the clinical data of 79 benign uterine lesions patients who underwent laparoscopic total hysterectomy in Changzhou Second People’s Hospital Affiliated to Nanjing Medical University from March 2018 to March 2020.The levels of sex hormones were measured before operation,one month after operation,and one year after operation,the modified Kupperman score scale was used to assess perimenopausal symptoms,the incidence of perimenopausal symptoms in patients with benign lesions undergoing laparoscopic total hysterectomy for one year after operation was counted,the influencing factors of perimenopausal symptoms in patients with benign lesions undergoing laparoscopic total hysterectomy were analyzed.Results A total of 79 patients were followed up for one year,and one patient was lost,which was not included in the statistics.One year after operation,the levels of estradiol,progesterone,and testosterone in patients with benign lesions undergoing laparoscopic total hysterectomy were lower than those of one month after operation and before operation,the levels of follicle stimulating hormone and luteinizing hormone were higher than those of one month after operation and before operation,and the differences were statistically significant(P<0.05);one month after operation,the levels of estradiol,progesterone,and testosterone in patients with benign lesions undergoing laparoscopic total hysterectomy were lower than those before operation,the levels of follicle stimulating hormone and luteinizing hormone were higher than those before operation,and the difference were statistically significant(P<0.05).One year after operation,perimenopausal symptoms occurred in 31 patients,and the incidence rate was 39.74%.Menopause and the levels of estradiol,progesterone,follicle stimulating hormone,luteinizing hormone,and testosterone were significantly different in

关 键 词：子宫良性病变 腹腔镜 子宫全切术 性激素 围绝经期症状 

分 类 号：R713.42[医药卫生—妇产科学]