房水中相关因子对康柏西普治疗湿性年龄相关性黄斑变性效果的影响  

Effect of Related Factors in Aqueous Humor on Conbercept in the Treatment of wAMD

作　　者：杭丽[1] 张传伟[1] 魏伟[2] HANG Li;ZHANG Chuanwei;WEI Wei(Jiangsu Province Hospital of Chinese Medicine,Nanjing,Jiangsu,China 210029;College of the First Clinical Medicine,Nanjing University of Chinese Medicine,Nanjing,Jiangsu,China 210029)

机构地区：[1]江苏省中医院,江苏南京210029 [2]南京中医药大学第一临床医学院,江苏南京210029

出　　处：《中国药业》2022年第8期57-60,共4页China Pharmaceuticals

基　　金：国家自然科学基金[81774370]。

摘　　要：目的探讨房水中血管内皮生长因子A(VEGFA)、色素上皮细胞衍生因子(PEDF)对康柏西普治疗湿性年龄相关性黄斑变性(wAMD)效果的影响。方法回顾性选取医院2018年1月至2020年6月收治的以康柏西普治疗的wAMD患者80例,根据疗效分为有效组和无效组,各40例。采用酶联免疫吸附(ELISA)法测定治疗前患者房水中VEGFA及PEDF水平。采用Logistic回归分析检验房水中VEGFA及PEDF水平对康柏西普治疗wAMD无效风险的影响;采用受试者工作曲线(ROC曲线)检验房水中中VEGFA及PEDF水平以预测康柏西普治疗wAMD无效风险的价值,以药-时曲线下面积(AUC)进行评价;采用Spearman直线相关检验分析房水中VEGFA水平与PEDF水平的相关性。结果无效组患者VEGFA水平显著高于有效组,PEDF水平显著低于有效组(P<0.05);Logistic回归分析结果表明,房水中VEGFA过表达是康柏西普治疗无效的风险因子[OR=1.110,95%CI(1.051,1.173),P<0.001],PEDF过表达是康柏西普治疗无效的保护因子[OR=0.976,95%CI(0.963,0.989),P<0.001];房水中VEGFA及PEDF水平预测康柏西普治疗无效风险的价值较理想(AUC>0.80);房水中VEGFA水平与PEDF水平呈负相关(r=-0.692,P=0.001)。结论wAMD患者治疗前房水中VEGFA及PEDF水平可能与康柏西普治疗wAMD的效果有关,VEGFA过表达及PEDF低表达可能增加康柏西普治疗无效的风险。ObjectiveTo investigate the effect of vascular endothelial growth factor A(VEGFA)and pigment epithelium-derived factor(PEDF)in aqueous humor on conbercept in the treatment of wet age-related macular degeneration(wAMD).Methods total of 80 patients with wAMD treated with conbercept from January 2018 to June 2020 were selected and divided into the effective group and the ineffective group according to the curative effect,with 40 cases in each group.The levels of VEGFA and PEDF in aqueous humor of patients before treatment were tested by enzyme-linked immunosorbent assay(ELISA).The effect of levels of VEGFA and PEDF in aqueous humor on the risk of ineffective treatment of wAMD with conbercept were tested by Logistic regression analysis.The value of VEGFA and PEDF levels in aqueous humor in predicting the risk of ineffective treatment of wAMD with conbercept was tested by receiver operator characteristic(ROC)curve,which was evaluated by area under the concentration time curve(AUC).The relevance between the levels of VEGFA and PEDF in aqueous humor was analyzed by the Spearman linear correlation test.Results than that of the effective group,the level of PEDF was significantly lower than that of the effective group(P<0.05).The results of Logistic regression analysis showed that the overexpression of VEGFA in aqueous humor was a risk factor for the ineffective treatment of conbercept[OR=1.110,95%CI(1.051,1.173),P<0.001],the overexpression of PEDF in aqueous humor was a protective factor for the ineffective treatment of conbercept[OR=0.976,95%CI(0.963,0.989),P<0.001].The levels of VEGFA and PEDF in aqueous humor were of ideal value in predicting the risk of the ineffective treatment with conbercept(AUC>0.80).There was a negative correlation between the level of VEGFA and the level of PEDF in aqueous humor of patients(r=-0.692,P=0.001).Conclusion curative effect of conbercept in the treatment of wAMD,and the overexpression of VEGFA and the low expression of PEDF in aqueous humor may increase the risk of the ineffective tre

关 键 词：康柏西普 湿性年龄相关性黄斑变性 血管内皮生长因子A 色素上皮细胞衍生因子 疗效 

分 类 号：R969.4[医药卫生—药理学] R988.1[医药卫生—药学]