单细胞RNA测序解析新型冠状病毒结合受体ACE2表达谱的研究进展  

Research progress in analyzing the expression profile of SARS-CoV-2 binding receptor ACE2 based on single-cell RNA sequencing

作　　者：王东升 岳新瑞 支德娟[1] Wang Dong-sheng;Yue Xin-rui;Zhi De-juan(School of Pharmacy,Lanzhou University,Lanzhou 730000,China;School of Animal Medicine and Bio-safety,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学药学院,甘肃兰州730000 [2]兰州大学动物医学与生物安全学院,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2022年第3期66-71,共6页Journal of Lanzhou University（Medical Sciences）

基　　金：兰州市科技局专项研究基金资助项目(2020-XG-32)。

摘　　要：血管紧张素转换酶2(ACE2)是细胞表面的功能性受体,在心脏、肾脏和肺等组织细胞中表达。新型冠状病毒(SARS-CoV-2)通过其刺突蛋白的受体结合域与ACE2受体结合,将遗传物质注入宿主细胞,扩增繁殖。ACE2受体在人体呼吸、消化、生殖、泌尿等系统中都具有广泛表达,但SARS-CoV-2进入机体细胞不仅依赖于ACE2受体,还与细胞成熟度以及辅助蛋白相关。本综述研究SARS-CoV-2感染患者单细胞RNA测序,解析ACE2受体表达谱在各个器官的特征,讨论其与疾病进展、临床结果和治疗潜力之间的病理生理学联系。Angiotensin-converting enzyme 2(ACE2)is a functional receptor on the cell surface,which is expressed in tissue cells such as those of the heart,kidney and lung.The SARS-CoV-2 binds to the ACE2receptor through its spike protein,injecting genetic material into host cells for amplification and reproduction.ACE2 receptors are widely expressed in the human respiratory,digestive,reproductive and urinary systems.The entry of SARS-CoV-2 into body cells is not only dependent on ACE2 receptors,but also related to cell maturity and accessory proteins.This reviews researched into single-cell RNA sequencing of patients with SARS-CoV-2,analyzed the characteristics of the ACE2 receptor expression profile in various organs,focused on the pathophysiological relationship between it and the disease progression,clinical outcome and therapeutic potentials.

关 键 词：血管紧张素转换酶2 新型冠状病毒 组织损伤 单细胞RNA测序 

分 类 号：R966[医药卫生—药理学]