新型大位阻氮杂环卡宾咪唑啉盐的合成  

Synthesis of Novel N-heterocyclic Carbene Imidazolinium Salts with Large Steric Hindrance

作　　者：沈安 陆辉扬 曹育才 SHEN An;LU Huiyang;CAO Yucai(Shanghai Research Institute of Chemical Industry Co.,Ltd.,Shanghai 200062,China;State Key Laboratory of Polyolefins and Catalysis,Shanghai 200062,China;Shanghai Key Laboratory of Catalysis Technology for Polyolefins,Shanghai 200062,China)

机构地区：[1]上海化工研究院有限公司,上海200062 [2]聚烯烃催化技术与高性能材料国家重点实验室,上海200062 [3]上海市聚烯烃催化技术重点实验室,上海200062

出　　处：《上海塑料》2022年第2期19-25,共7页Shanghai Plastics

摘　　要：氮杂环卡宾类化合物性质独特,能作为配体与多种过渡金属配位形成稳定的配合物,被广泛应用于各类催化反应。氮杂环卡宾类化合物化学结构的变化能直接影响其作为配体在催化反应中所产生的电子效应和空间位阻效应。引入大位阻基团吗啉和吡咯烷,通过还原、缩合、酰化、环化等反应,成功合成结构新颖的2种大位阻取代氮杂环卡宾氯化咪唑啉盐,反应总产率分别为23%和11%。该类新型氮杂环卡宾咪唑啉盐极大拓展了氮杂环卡宾配体的结构类型,为催化反应的配体选型提供了更丰富的可能性。With unique characteristic,N-heterocyclic carbenes can be applied widely as appropriate ligands for a wide range of transition metal in catalytic reaction.The change of chemical structure of N-heterocyclic carbenes can directly affect the electronic effect and steric hindrance effect as ligands in catalytic reactions.By introducing morpholine and pyrrolidine with large steric hindrance groups,two kinds of novel N-heterocyclic carbenes imidazolinium chlorides have been synthesized via several steps by reduction,condensation,acylation and cyclization reactions.The total yields of the reactions are 23% and 11% respectively.The novel N-heterocyclic carbene imidazolinium salts greatly expand the structural types of N-heterocyclic carbene ligands and provide more possibilities for the selection of ligands for catalytic reactions.

关 键 词：氮杂环卡宾 氯化咪唑啉盐 吗啉 吡咯烷 大位阻配体 合成方法 

分 类 号：TQ252[化学工程—有机化工]