氨基末端脑钠肽前体联合中性粒细胞与淋巴细胞比值对静脉丙种球蛋白无反应性川崎病预测价值  

Predictive value of N-terminal pro brain natriuretic peptide combined with neutrophil lymphocyte ratio in intravenous immunoglobulin unresponsive Kawasaki disease

作　　者：邓建荣[1] 林小芹 阮豫才[1] 彭丽君 聂煜晢 肖小兵[1] DENG Jianrong;LIN Xiaoqin;RUAN Yucai;PENG Lijun;NIE Yuzhe;XIAO Xiaobing(Department of Pediatrics,North Guangdong People's Hospital,Guangdong Province,Shaoguan 512026,China;Department of Pediatrics,Shaoguan First People's Hospital,Guangdong Province,Shaoguan 512026,China)

机构地区：[1]广东省韶关市粤北人民医院儿科,广东韶关512026 [2]广东省韶关市第一人民医院儿科,广东韶关512026

出　　处：《中国当代医药》2022年第8期21-24,共4页China Modern Medicine

基　　金：广东省韶关市卫生健康科研项目(Y20145)。

摘　　要：目的探讨氨基末端脑钠肽前体联合中性粒细胞与淋巴细胞比值对静脉丙种球蛋白无反应性川崎病预测价值。方法选取2019年1月至2021年7月粤北人民医院儿科收治的120例川崎病患儿作为研究对象,按照对丙种球蛋白是否有反应分成无反应组、敏感组,各60例,同时收集健康体检儿童30例为对照组,对三组研究对象进行血清检测和心脏彩超检测,比较三组研究对象的氨基末端脑钠肽前体、中性粒细胞与淋巴细胞比值、白细胞计数、C反应蛋白、血小板、红细胞沉降率、白蛋白、血钠水平,采用Pearson分析氨基末端脑钠肽前体与白细胞计数、C反应蛋白、血小板、红细胞沉降率、白蛋白、血钠水平的相关性,绘制ROC曲线分析氨基末端脑钠肽前体和中性粒细胞与淋巴细胞比值单独及联合检测对川崎病的预测价值。结果无反应组、敏感组的氨基末端脑钠肽前体、中性粒细胞与淋巴细胞比值、白细胞计数、C反应蛋白、血小板、红细胞沉降率均高于对照组,白蛋白、血钠水平低于对照组,差异有统计学意义(P<0.05);无反应组和敏感组的氨基末端脑钠肽前体、中性粒细胞与淋巴细胞比值、白细胞计数、C反应蛋白、血小板、红细胞沉降率、白蛋白、血钠水平比较,差异无统计学意义(P>0.05)。氨基末端脑钠肽前体与白细胞计数、C反应蛋白呈正相关(P<0.05),氨基末端脑钠肽前体与白蛋白、血钠水平呈负相关(P<0.05),氨基末端脑钠肽前体与血小板、红细胞沉降率无相关性(P>0.05)。氨基末端脑钠肽前体诊断丙种球蛋白无反应性川崎病的敏感度、特异度为66.67%和80.00%,二者联合检测诊断丙种球蛋白无反应性川崎病的敏感度、特异度为91.67%和96.67%。结论氨基末端脑钠肽前体联合中性粒细胞与淋巴细胞比值不仅有助于静脉丙种球蛋白无反应性川崎病的诊断,同时具有良好的预测冠状动脉损�Objective To investigate the predictive value of N-terminal pro brain natriuretic peptide combined with the ratio of neutrophils to lymphocytes in intravenous immunoglobulin unresponsive Kawasaki disease.Methods A total of 120 children with Kawasaki disease treated in pediatrics of North Guangdong People's Hospital from January 2019 to July 2021 were selected as the research objects.According to whether they responded to gamma globulin,they were divided into non response group and sensitive group,with 60 cases in each group.At the same time,30 healthy children were collected as the control group.The three groups of research objects were tested by serum and color Doppler echocardiography.The levels of amino terminal brain natriuretic peptide precursor,neutrophil lymphocyte ratio,leukocyte count,C-reactive protein,platelet,erythrocyte sedimentation rate,albumin and blood sodium of the three groups were compared.Pearson correlation analysis was used to analyze the correlation between amino terminal brain natriuretic peptide precursor and leukocyte count,C-reactive protein,platelet,erythrocyte sedimentation rate,albumin and blood sodium,ROC curve analysis of the predictive value of amino terminal pro brain natriuretic peptide and the ratio of neutrophils to lymphocytes in the diagnosis of Kawasaki disease alone and in combination.Results The amino terminal brain natriuretic peptide precursors,neutrophil to lymphocyte ratio,white blood cell count,C-reactive protein,platelet and erythrocyte sedimentation rate were higher in non-reactive group and sensitive group than those in control group,while the levels of albumin and serum sodium were lower than those in control group,the differences were statistically significant(P<0.05).There were no significant differences in amino terminal brain natriuretic peptide precursors,neutrophil to lymphocyte ratio,white blood cell count,C-reactive protein,platelet,erythrocyte sedimentation rate,albumin and serum sodium levels between non-reaction group and sensitive group(P>0.05).The a

关 键 词：川崎病 丙种球蛋白 氨基末端脑钠肽前体 中性粒细胞与淋巴细胞比值 

分 类 号：R543[医药卫生—心血管疾病]