2型糖尿病患者种植体龈沟液炎症因子与种植体周健康的研究  

Study of inflammatory factors in implants gingival crevicular fluid and peri-implant health in patients with type 2 diabetes mellitus

作　　者：陈瑾[1] 方慧 况莉 江燕 CHEN Jin;FANG Hui;KUANG Li;JIANG Yan(Department of Stomatology,Pingxiang People's Hospital,Jiangxi Province,Pingxiang 337000,China)

机构地区：[1]江西省萍乡市人民医院口腔科,江西萍乡337000

出　　处：《中国当代医药》2022年第8期111-113,共3页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202140495)。

摘　　要：目的探索2型糖尿病(T2DM)诱导的炎症细胞因子对种植体周组织的影响。方法选取2020年8月至2021年8月萍乡市人民医院口腔科32例行种植体植入术并上部全瓷冠修复的T2DM患者作为观察组,选取同期32例血糖正常的拟行种植体植入术并上部全瓷冠修复的种植牙患者作为对照组。比较两组牙周探诊深度(PD)、龈沟出血指数(SBI)、种植体龈沟液(PISF)量以及PISF中白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平的表达。结果两组的PD、SBI比较,差异无统计学意义(P>0.05)。行种植术后,观察组的PISF低于对照组,观察组PISF表达的IL-1β、TNF-α高于对照组,差异有统计学意义(P<0.05),两组的IL-6水平比较,差异无统计学意义(P>0.05)。观察组的PISF与IL-1β、TNF-α呈负相关(r=-0.482、-0.436,P<0.05)。结论T2DM患者的PISF量较同期健康种牙者少,但PISF中的IL-1β、TNF-α表达量高。Objective To explore the effects of inflammatory cytokines induced by type 2 diabetes mellitus(T2DM)on peri-implant tissues.Methods A total of 32 patients with T2DM undergoing implant implantation and upper all-ceramic crown repair in stomatology department of Pingxiang People's Hospital were enrolled as observation group between August 2020 and August 2021,while other 32 patients with normal blood glucose during the same period were enrolled as control group.The probing depth(PD),sulcus bleeding index(SBI),volume of peri-implant sulcular fluid(PISF),expression levels of interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in PISF of the two groups were statistically analyzed.Results There were no significant differences in PD and SBI between the two groups(P>0.05).After implantation,the PISF in observation group was lower than that in control group,expressions of IL-1β and TNF-α in PISF of observation group were higher than those in control group,the differences were statistically significant(P<0.05),but there was no significant difference in IL-6 between the two groups(P>0.05).PISF was significantly negatively correlated with IL-1β and TNF-α(r=-0.482,-0.436,P<0.05).Conclusion Compared with patients with healthy implant teeth,PISF volume is less,while expressions of IL-1β and TNF-α were higher in T2DM patients.

关 键 词：2型糖尿病 种植体 龈沟液 炎症因子 牙周健康状况 

分 类 号：R587.1[医药卫生—内分泌]