1,2,4-三甲基苯氧化制备2,3,5-三甲基苯醌的技术进展  

Technical progress in the oxidation of 1, 2, 4-trimethylbenzene to 2, 3, 5-trimethylbenzoquinone

作　　者：李彬[1,3] 李佩玉 姜爽 张天永 LI Bin;LI Peiyu;JIANG Shuang;ZHANG Tianyong(Tianjin Key Laboratory of Applied Catalysis Science and Technology,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300350,China;Collaborative Innovation Center of Chemical Science and Engineering(Tianjin),Tianjin 300072,China;Tianjin Engineering Research Center of Functional Fine Chemicals,Tianjin 300350,China)

机构地区：[1]天津大学化工学院精细化工系,天津市应用催化科学与工程重点实验室,天津300350 [2]天津化学化工协同创新中心,天津300072 [3]天津市功能精细化学品技术工程中心,天津300350

出　　处：《化学工业与工程》2022年第1期40-50,共11页Chemical Industry and Engineering

基　　金：国家自然科学基金项目(21908161);天津市自然科学基金(16JCYBJC20800);天津市科技创新平台计划(14TXGCCX00017)。

摘　　要：2, 3, 5-三甲基苯醌(TMBQ)是合成维生素E的关键中间体,以1, 2, 4-三甲基苯(TMB)为原料经一步氧化制备TMBQ原子经济性高,三废少,是最具应用潜力的下一代维生素E中间体绿色制备技术,有望显著降低生产成本。针对该技术路线,系统综述了近年来TMB一步催化氧化合成TMBQ的研究进展,着重分析了不同催化氧化体系对TMB选择性氧化的影响规律,展望了TMB一步合成TMBQ技术的工业应用前景。2, 3, 5-trimethylbenzoquinone(TMBQ) is a key intermediate for the synthesis of vitamin E. Using 1, 2, 4-trimethylbenzene(TMB) as a raw material to prepare TMBQ through one-step oxidation has high atomic economy and less three wastes. It is the next-generation key technology with the most application potential, which might significantly reduce production costs of vitamin E. For this technical route, the research progress in the synthesis of TMBQ from TMB by one-step catalytic oxidation in recent years was systematically reviewed. The effects of different catalytic systems on the selective oxidation of TMB were analyzed and summarized, the industrial application of direct oxidation technology of TMB to TMBQ was also prospected.

关 键 词：1 2 4-三甲基苯 2 3 5-三甲基苯醌 催化 氧化 双氧水 

分 类 号：TQ244.6[化学工程—有机化工]