血清H-FABP、25-OH-VitD3检测联合心脏彩超在评估老年性心力衰竭预后中的价值  

The value of serum H-FABP and 25-OH-VitD3 combined with ultrasonic cardiogram in evaluating the prognosis of senile heart failure

作　　者：王广弟 郭照军 黄茂芹[2] 廖煌 WANG Guangdi;GUO Zhaojun;HUANG Maoqin;LIAO Huang(Second District Department of Cardiology,the Second Affiliated Hospital of Hainan Medical University,Haikou,Hainan 570311,China;Department of Cardiology,the Second Affiliated Hospital of Hainan Medical University,Haikou,Hainan 570311,China)

机构地区：[1]海南医学院第二附属医院心血管科二区,海南海口570311 [2]海南医学院第二附属医院心血管科,海南海口570311

出　　处：《国际检验医学杂志》2022年第8期921-924,928,共5页International Journal of Laboratory Medicine

基　　金：海南省自然科学基金面上项目(818MS132)。

摘　　要：目的探讨血清心型脂肪酸结合蛋白(H-FABP)、25羟基维生素D3(25-OH-VitD3)检测联合心脏彩超在评估老年性心力衰竭患者预后中的价值。方法采用前瞻性研究方法,选取2018年1月至2020年1月诊断的老年性心力衰竭患者132例(观察组)作为研究对象,观察组根据美国纽约心脏病协会(NYHA)分级标准分为Ⅰ~Ⅱ级患者88例,Ⅲ~Ⅳ级患者44例。另选取同期在该院体检的健康志愿者132例作为对照组。比较观察组、对照组及观察组不同NYHA分级患者左心室收缩期末容积(LVESV)、左心室舒张期末容积(LVEDV)、左心室射血分数(LVEF)、H-FABP、25-OH-VitD3水平差异,以及5项指标联合检测对观察组患者死亡预测的效能分析。结果观察组LVEF、25-OH-VitD3水平明显低于对照组,LVESV、LVEDV、H-FABP水平明显高于对照组,差异有统计学意义(P<0.05);观察组Ⅰ~Ⅱ级患者LVEF、25-OH-VitD3水平明显高于Ⅲ~Ⅳ级患者,LVESV、LVEDV、H-FABP水平明显低于Ⅲ~Ⅳ级患者,差异有统计学意义(P<0.05)。生存组LVEF、25-OH-VitD3水平明显高于死亡组,而LVESV、LVEDV、H-FABP明显低于死亡组,差异有统计学意义(P<0.05)。结论血清H-FABP、25-OH-VitD3检测联合心脏彩超在评估老年性心力衰竭患者预后中具有重要临床意义,值得临床推广应用。Objective To explore the value of serum heart type fatty acid binding protein(H-FABP)and 25-hydroxyvitamin D3(25-OH-VitD3)combined with ultrasonic cardiogram in evaluating the prognosis of elderly patients with heart failure.Methods Using the prospective research method,132 patients with senile heart failure diagnosed from January 2018 to January 2020(observation group)were selected as the research object.The observation group was divided into 88 patients with gradeⅠ-Ⅱand 44 patients with gradeⅢ-Ⅳaccording to the classification standard of New York Heart Association(NYHA).In addition,132 healthy volunteers who underwent physical examination in the hospital in the same period were selected as the control group.The levels of left ventricular end systolic volume(LVESV),left ventricular end diastolic volume(LVEDV),left ventricular ejection fraction(LVEF),H-FABP and 25-OH-VitD3 in patients with different NYHA grades in the observation group,the control group and the observation group were compared,as well as the efficacy of five combined tests in predicting the death of patients in the observation group.Results LVEF and 25-OH-VitD3 in the observation group were significantly lower than those in the control group,while LVESV,LVEDV and H-FABP were significantly higher than those in the control group,the differences were statistically significant(P<0.05).In observation group,the levels of LVEF and 25-OH-VitD3 in gradeⅠ-Ⅱpatients were significantly higher than those in gradeⅢ-Ⅳpatients,while the levels of LVESV,LVEDV and H-FABP were significantly lower than those in gradeⅢ-Ⅳpatients,the differences were statistically significant(P<0.05).The levels of LVEF and 25-OH-VitD3 in survival group were significantly higher than those in death group,while LVESV,LVEDV and H-FABP were significantly lower than those in death group,the differences were statistically significant(P<0.05).Conclusion Serum H-FABP and 25-OH-VitD3 combined with ultrasonic cardiogram has important clinical significance in evaluating the pr

关 键 词：心型脂肪酸结合蛋白 25羟基维生素D3 心脏彩超 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]