IC及FEV1在COPD和ACO鉴别诊断中的应用价值  

Application value of IC and FEV1 in differential diagnostic of COPD and ACO

作　　者：伍灿 杨娟[1] 谢婧军 WU Can;YANG Juan;XIE jingjun(Department of Respiratory,Chongqing Traditional Chinese Medicine Hospital,Chongqing 400020,China;Department of Geriatrics and Special Service Medicine,First Affiliated Hospital of Army Medical University,Chongqing 400038,China)

机构地区：[1]重庆市中医院呼吸科,重庆400020 [2]陆军军医大学第一附属医院老年医学与特勤医学科,重庆400038

出　　处：《检验医学与临床》2022年第8期1018-1021,共4页Laboratory Medicine and Clinic

基　　金：重庆市自然科学基金项目(cstc2018jxj1130024)。

摘　　要：目的研究深吸气量(IC)及第1秒用力呼气容积(FEV1)在慢性阻塞性肺疾病(COPD)与哮喘-慢阻肺重叠综合征(ACO)鉴别诊断中的应用价值。方法收集2019年4月到2021年4月重庆市中医院及陆军军医大学第一附属医院收治的52例COPD患者作为COPD组,58例ACO患者作为ACO组。检测所有患者肺功能,比较COPD组及ACO组IC、FEV1,采用受试者工作特征曲线分析IC、FEV1单独检测鉴别诊断ACO与COPD的价值,采用一致性分析IC、FEV1联合鉴别诊断ACO与COPD的价值,采用Spearman相关分析IC、FEV1与患者肺功能分级的关系。结果ACO组IC、FEV1均低于COPD组(P<0.05)。患者IC、FEV1随肺功能分级升高而减低,差异具有统计学意义(P<0.05)。IC、FEV1单独检测鉴别诊断ACO与COPD的曲线下面积分别为0.760、0.835;IC、FEV1联合鉴别诊断ACO与COPD的灵敏度为0.759,特异度为0.788,准确率为0.773,Kappa值为0.488。IC、FEV1均与肺功能分级呈负相关(P<0.05)。结论IC、FEV1对ACO与COPD均有一定鉴别诊断价值,且二者联合鉴别诊断效能更高。Objective To study the application value of deep inspiratory capacity(IC)and forced expiratory volume in one second(FEV1)in the differential diagnosis of chronic obstructive pulmonary disease(COPD)and asthma COPD overlap syndrome(ACO).Methods From April 2019 to April 2021,52 patients with COPD and 58 patients with ACO admitted to the Chongqing Traditional Chinese Medicine Hospital and the First Affiliated Hospital of Army Medical University were collected as the COPD group and the ACO group.The pulmonary function of all patients was detected,the IC and FEV1 of the COPD group and the ACO group were compared,the receiver operating characteristic curve was used to analyze the value of IC and FEV1 alone in the differential diagnosis of ACO and COPD,the consistency analysis of the value of IC and FEV1 in the differential diagnosis of ACO and COPD was used,and the relationship between IC and FEV1 and the patient′s pulmonary function classification was analyzed by Spearman related.Results IC and FEV1 in the ACO group were lower than those in the COPD group(P<0.05).IC and FEV1 decreased with the increase of pulmonary function grade,and the difference was statistically significant(P<0.05).The areas under the curve of IC and FEV1 for the differential diagnosis of ACO and COPD were 0.760 and 0.835,respectively.The sensitivity of IC and FEV1 in the differential diagnosis of ACO and COPD was 0.759,specificity was 0.788,accuracy was 0.773,and Kappa value was 0.488.IC and FEV1 were negatively correlated with pulmonary function grade(P<0.05).Conclusion IC and FEV1 have certain differential diagnostic value for ACO and COPD,and the combination of the two has differential higher diagnostic efficiency.

关 键 词：深吸气量 第1秒用力呼气容积 慢性阻塞性肺疾病 哮喘-慢阻肺重叠综合征 

分 类 号：R563.9[医药卫生—呼吸系统] R562.2[医药卫生—内科学]