PDMDAAC改性玉米醇溶蛋白负载阿维菌素纳米颗粒的制备与性能  

Preparation and properties of Avermectin-loaded PDMDAAC modified Zein nanoparticles

作　　者：李梓泳 陈龙 马文丹 周红军[1] 周新华[1,2] LI Ziyong;CHEN Long;MA Wendan;ZHOU Hongjun;ZHOU Xinhua(Innovative Institute for Plant Health,Key Laboratory of Agricultural Green Fine Chemicals of Guangdong Higher Education Institution,School of Chemistry and Chemical Engineering,Zhongkai University of Agriculture and Engineering,Guangzhou 510225,Guangdong,China;Maoming Branch,Guangdong Laboratory for Lingnan Modern Agriculture,Maoming 525000,Guangdong,China)

机构地区：[1]植物健康创新研究院,仲恺农业工程学院化学化工学院,广东省普通高校农用绿色精细化学品重点实验室,广东广州510225 [2]岭南现代农业科学与技术广东省实验室茂名分中心,广东茂名525000

出　　处：《化工进展》2022年第4期2068-2074,共7页Chemical Industry and Engineering Progress

基　　金：广东省农业产业技术体系共性关键技术(农业纳米)创新团队(2019KJ140);广东省教育厅农用绿色精细化学品科技创新团队(2018KCXTD015);广州市科技计划(201903010011)

摘　　要：为提高阿维菌素叶面沉积率及其抗紫外分解性能,本文设计构建了叶面亲和的纳米载体。通过自由基聚合将聚二甲基二烯丙基氯化铵(PDMDAAC)改性玉米醇溶蛋白(Zein),得到表面携带正电荷的改性玉米醇溶蛋白,并将其用于负载阿维菌素。采用红外光谱(FTIR)、扫描电镜(SEM)等手段对改性产物结构和形貌进行表征。通过反溶剂沉淀法制备了平均粒径为64.92nm的载药纳米粒子,载体对阿维菌素的包封率为(34.75±0.18)%。与植物表面的静电作用提升了纳米粒子悬浮液在植物表面的润湿性能,接触角大小随PDMDAAC接枝量增大而降低,由77.38°减小到64.60°;叶面滞留量可达33.69mg/cm^(2)。改性玉米醇溶蛋白对阿维菌素的包覆提升了其抗紫外性能,半衰期由15min延长至40min,且阿维菌素的释放速率可通过PDMDAAC接枝率进行调控。In order to improve the leaf deposition rate of avermectin and its resistance to UV decomposition,a foliar affinity nanocarrier was designed.By free radical polymerization,dimethyldiallylammonium chloride(PDMDAAC)was used to modify Zein,and the modified Zein with positive charge on the surface was obtained,which was used to load avermectin.The drug-carrying nanoparticles with an average particle size of 64.92nm were prepared by anti-solvent precipitation method.The encapsulation efficiency of avermectin was(34.75±0.18)%.The electrostatic interaction with the plant surface improved the wettability of the suspension,and the contact angle decreased from 77.38°to 64.60°with the increase of the amount of PDMDAAC grafting.Leaf retention reached 33.69mg/cm^(2).Avermectin coated with modified Zein improved the UV resistance,the half-life was extended from 15min to 40min,and the release rate of avermectin was regulated by the grafting rate of PDMDAAC.

关 键 词：聚二甲基二烯丙基氯化铵 玉米醇溶蛋白 阿维菌素 缓释 抗紫外 

分 类 号：TQ450.6[化学工程—农药化工]