电子加速器生产医用同位素钼-99的发展现状与展望  

Development Status and Prospect for the Medical Isotope Molybdenum-99 Produced by Electron Accelerator

作　　者：王怡 郭子方 王兰 李姣龙 焦力敏 高璇 翁汉钦 林铭章[1] WANG Yi;GUO Zifang;WANG Lan;LI Jiaolong;JIAO Limin;GAO Xuan;WENG Hanqin;LIN Mingzhang(School of Nuclear Science and Technology,University of Science and Technology of China,Hefei 230026,China;National Synchrotron Radiation Laboratory,University of Science and Technology of China,Hefei 230029,China;Beijing Zhibo Bio-medical Technology Co.,Ltd,Beijing 102502,China)

机构地区：[1]中国科学技术大学核科学技术学院,安徽合肥230026 [2]中国科学技术大学国家同步辐射实验室,安徽合肥230029 [3]北京智博高科生物技术有限公司,北京102502

出　　处：《同位素》2022年第2期114-127,共14页Journal of Isotopes

摘　　要：^(99)Mo的衰变子体^(99)m Tc是核医学领域中应用最广泛的放射性同位素,近年全球主要的^(99)Mo生产堆面临着非计划检修及关停退役等问题,导致其供应不稳定,因此多个发达国家已在积极开发^(99)Mo生产的替代性技术。本文介绍了多种利用粒子加速器代替反应堆生产^(99)Mo的技术路线,总结了电子加速器生产^(99)Mo的国内外研究进展,详细论述了加速器性能指标和照射装置与靶件设计、^(99)m Tc分离提取、100 Mo回收利用以及废物管理等关键技术,为国内有关技术的基础、应用研究与电子加速器生产^(99)Mo的商业化提出建议。As the decay daughter of^(99)Mo,99m Tc is the most widely used radioisotope in the field of nuclear medicine.Recently,the major^(99)Mo production reactors in the world are facing problems such as unplanned maintenance,shutdown and decommission,resulting in the unstable supply of^(99)Mo.Therefore,many developed countries have been actively exploiting alternative technologies for^(99)Mo production.In this paper,various^(99)Mo-production technologies by particle accelerator instead of reactor were introduced,and the research progress of producing^(99)Mo based on electron accelerator was summarized at home and abroad.The accelerator performance index and the key technologies in the production process were discussed in detail,such as the design of irradiation device and target,separation of 99m Tc,recovery of 100 Mo and waste management.In addition,some suggestions were put forward for the basic and applied research of relevant technologies in China and the commercialization of^(99)Mo production by electron accelerator.

关 键 词：电子加速器 医用同位素 ^(99)Mo ^(99)m Tc 光核反应 

分 类 号：TL921[核科学技术—核燃料循环与材料]