穴位埋线联合枸地氯雷他定片对肺脾气虚型变应性鼻炎疗效及患者血清IL-33水平的影响  

Therapeutic Efficacy of Acupoint Thread Embedding Combined with Desloratadine Citrate Disodium Tablets for Allergic Rhinitis Due to Lung-spleen Qi Deficiency and Its Effect on the Serum IL-33 Level

作　　者：伍志刚 李秀彬 章仁宏 陈筱 王海梁 侯俊伟 WU Zhigang;LI Xiubin;ZHANG Renhong;CHEN Xiao;WANG Hailiang;HOU Junwei(Zhejiang Wenling Hospital of Traditional Chinese Medicine,Wenling 317500,China)

机构地区：[1]浙江省温岭市中医院,温岭317500

出　　处：《上海针灸杂志》2022年第4期396-399,共4页Shanghai Journal of Acupuncture and Moxibustion

基　　金：台州市社会发展科技计划项目(20ywb145);温岭市社会发展科技项目(2018C312016)。

摘　　要：目的观察穴位埋线联合枸地氯雷他定片治疗肺脾气虚型变应性鼻炎(AR)患者的临床疗效及对患者血清白细胞介素33(IL-33)水平的影响。方法选取符合纳入标准的肺脾气虚型AR患者64例,随机分为两组。对照组32例,予口服枸地氯雷他定片治疗;治疗组32例,在对照组治疗基础上联合穴位埋线治疗。比较两组治疗前后鼻症状总积分(TNSS)及鼻炎伴随症状总分(TNNSS),比较治疗前后两组患者血清IL-33水平的变化,评价两组治疗的安全性。结果治疗前,两组患者TNSS、TNNSS评分比较,差异无统计学意义(P>0.05)。治疗后,两组TNSS和TNNSS评分均低于同组治疗前比较,差异均具有统计学意义(P<0.05);且治疗组TNSS和TNNSS评分均明显低于对照组(P<0.05)。治疗前,两组患者血清IL-33水平比较,差异无统计学意义(P>0.05)。治疗后,两组患者血清IL-33水平均较同组治疗前明显降低(P<0.05);且两组组间比较差异具有统计学意义(P<0.05)。治疗过程中,两组均未发生明显不良反应事件。结论穴位埋线联合枸地氯雷他定片治疗肺脾气虚型变应性鼻炎的疗效优于单纯枸地氯雷他定片治疗,可能与穴位埋线有助于降低血清IL-33水平有关。Objective To observe the clinical efficacy of acupoint thread embedding plus Desloratadine citrate disodium tablets in treating allergic rhinitis(AR)due to lung-spleen Qi deficiency and its effect on the serum interleukin(IL)-33 level.Method Sixty-four eligible patients with AR of lung-spleen Qi deficiency pattern were selected and randomized into two groups.Thirty-two cases in the control group were offered oral administration of Desloratadine citrate disodium tablets;the other thirty-two cases in the treatment group were given additional acupoint thread embedding.Before and after the treatment,the total nasal symptoms score(TNSS),total non-nasal symptoms score(TNNSS),and serum IL-33 level in the two groups were compared.Safety was also rated.Result Before the treatment,there were no significant between-group differences in the TNSS and TNNSS(P>0.05).After the treatment,the TNSS and TNNSS dropped in both groups,and the changes were statistically significant(P<0.05);the TNSS and TNNSS were significantly lower in the treatment group than in the control group(P<0.05).Before the treatment,there was no significant difference in the serum IL-33 level between the two groups(P>0.05).After the treatment,the serum IL-33 level declined significantly in both groups(P<0.05),and the between-group difference was also statistically significant(P<0.05).During the treatment process,there were no significant adverse reactions in the two groups.Conclusion Acupoint thread embedding plus Desloratadine citrate disodium tablets can produce more significant efficacy than using Desloratadine citrate disodium tablets alone in treating AR of lung-spleen Qi deficiency pattern,which may be associated with the assistance of acupoint thread embedding in down-regulating the serum IL-33 level.

关 键 词：穴位埋线 针药并用 鼻炎 变应性 肺脾气虚 白介素33 炎症因子 

分 类 号：R246.82[医药卫生—针灸推拿学]