养阴通络方联合硫酸羟氯喹片对阴虚血燥证原发性干燥综合征患者细胞因子的影响  

Effect of Yangyin Tongluo Recipe combined with hydroxychloroquine sulfate tablets on cytokines in patients with primary Sj?gren’s syndrome of Yin deficiency and blood dryness syndrome

作　　者：郝明月 周晓莉[2] 乔平平 王超 陈玉珍[2] HAO Mingyue;ZHOU Xiaoli;QIAO Pingping;WANG Chao;CHEN Yuzhen(Shanxi University of Chinese Medicine,Taiyuan,Shanxi 030024,China;Department of Rheumatology,ShanxiHospital of Traditional Chinese Medicine,Taiyuan,Shanxi 030012,China)

机构地区：[1]山西中医药大学,山西太原030024 [2]山西省中医院风湿病科,山西太原030012

出　　处：《湖南中医药大学学报》2022年第4期689-693,共5页Journal of Hunan University of Chinese Medicine

基　　金：山西中医药大学科技创新能力培育计划项目(2019PY-041);山西省中医药管理局陈玉珍省级名中医传承工作室建设项目(SXSMZYGZS005)。

摘　　要：目的 观察养阴通络方联合硫酸羟氯喹片治疗阴虚血燥证原发性干燥综合征(primary Sj?gren syndrome,PSS)患者的临床疗效及其对细胞因子的调节作用。方法 选取2019年11月至2020年10月山西省中医院风湿病科门诊51例阴虚血燥证PSS患者,随机分为观察组(26例)和对照组(25例)。对照组予硫酸羟氯喹片,口服,每次0.2 g,1日2次,观察组在对照组基础上联用养阴通络方,两组均治疗12周。观察两组临床疗效及治疗前后γ干扰素(interferon-γ,IFN-γ)、白细胞介素-4(interleukin-4,IL-4)、白细胞介素-17(interleukin-17,IL-17)、白细胞介素-6(interleukin-6,IL-6)、欧洲抗风湿病联盟干燥综合征患者报告指数(European league against rheumatism Sj?gren syndrome patient reported index,ESSPRI)的变化。结果 观察组临床总有效率为88.46%,对照组临床总有效率为64.00%,观察组明显高于对照组(P<0.05)。治疗后,两组IFN-γ、IL-4、IL-17、IL-6、ESSPRI较治疗前均明显降低(P<0.05),且观察组IFN-γ、IL-4、IL-17、IL-6、ESSPRI均明显低于对照组(P<0.05)。结论 养阴通络方联合硫酸羟氯喹片可改善阴虚血燥证PSS患者的口干、眼干症状,调节细胞因子水平。Objective To observe the clinical efficacy of Yangyin Tongluo Recipe combined with hydroxychloroquine sulfate tablets in the treatment of primary Sj?gren’s syndrome(PSS) with Yin deficiency and blood dryness syndrome and its regulation on cytokines.Methods 51 patients with PSS of Yin deficiency and blood dryness syndrome were enrolled from November 2019 to October 2020 in the Department of Rheumatology,Shanxi Hospital of Traditional Chinese Medicine and randomly divided into observation group(26 cases) and control group(25 cases).The control group was given 0.2 g hydroxychloroquine sulfate tablets,twice a day,and the observation group was given Yangyin Tongluo Recipe on the basis of the control group,both groups were treated for 12 weeks.The clinical efficacy and the changes of interferon-γ(IFN-γ),interleukin-4(IL-4),interleukin-17(IL-17),interleukin-6(IL-6),and European league against rheumatism Sj?gren syndrome patient reported index(ESSPRI) were observed before and after treatment.Results The total clinical effective rate of the observation group(88.46%) was better than that of the control group(64%)(P<0.05).After treatment,IFN-γ,IL-4,IL-17,IL-6 and ESSPRI in 2 groups were significantly decreased compared with before treatment(P<0.05),and IFN-γ,IL-4,IL-17,IL-6 and ESSPRI in observation group were significantly lower than those in control group(P <0.05).Conclusion Yangyin Tongluo Recipe combined with hydroxychloroquine sulfate tablets can improve the symptoms of dry mouth and dry eyes in patients with PSS with Yin deficiency and blood dryness syndrome,and can also regulate the level of cytokines.

关 键 词：原发性干燥综合征 羟氯喹 养阴通络方 细胞因子 Γ干扰素 白细胞介素-4 白细胞介素-6 白细胞介素-17 

分 类 号：R259[医药卫生—中西医结合]