我院2018-2020年药品不良反应679例报告分析  

Analysis on Report of 679 Cases of Adverse Drug Reaction in Our Hospital from 2018 to 2020

作　　者：蒋凯 张乐[1] 王娆 张春玲[1] 张丽心[1] JIANG Kai;ZHANG Le;WANG Rao;ZHANG Chunling;ZHANG Lixin(Honghui Hospital Affiliated to Xi'an Jiaotong University,Xi'an Shanxi 710000,China)

机构地区：[1]西安交通大学附属红会医院,陕西西安710000

出　　处：《药品评价》2022年第3期129-132,共4页Drug Evaluation

基　　金：陕西省重点研发项目(2018SF-146)。

摘　　要：目的:探讨药品不良反应(ADR)发生的规律和特点,为临床合理使用提供参考。方法:从报告级别、患者性别及年龄、引发ADR的给药途径、ADR累及器官和(或)系统及主要临床表现等方面对西安交通大学附属红会医院2018-2020年上报国家药品不良反应管理平台的679例ADR报告进行统计分析。结果:679例ADR报告中,一般的ADR 630例(占92.78%),严重的ADR 42例(占6.19%),新的一般的ADR 6例(占0.88%),新的严重的ADR 1例(占0.15%),严重的ADR共43例(占6.34%)。男性患者334例(占49.19%),女性患者345例(占50.81%),其中50~60岁的患者最多,145例(占21.35%),且严重的ADR中,该年龄段人数最多10例(占1.47%)。静脉滴注致ADR最为常见,其次为口服给药ADR主要累及皮肤及其附件,其次为消化系统及循环系统。结论:ADR的发生与多种因素相关,医疗机构加强对ADR的监测十分必要,同时应加强医药合作,积极发挥临床药师作用,促进合理用药。Objective:To discuss the rules and characteristics of 679 cases of adverse drug reactions (ADR) reported to the National Adverse Drug Response Management Platform by Honghui Hospital of Xi’an Jiaotong University from 2018 to 2020,so as to provide reference for the rational drug use in clinic.Method:There were 679 cases of ADR,statistical analysis was conducted on application data in terms of reporting level,patient’s age and gender,route of administration of ADR,ADR involved organs and (or) systems and main clinical manifestations.Result:In the 679 ADR reports,630 cases (92.78%) were general ADR,42 cases (6.19%) were severe ADR,6 cases (0.88%) were new general ADR,1 case (0.15%) was new severe ADR,and 43 cases (6.34%) were the total number of severe ADR.Meanwhile,334 cases (49.19%) were males and 345 cases (50.81%) were females,ADR occurred in all age groups,patients aged 50-60 years old were the most (145 cases,21.35%),and the number of new severe ADR were the largest (10 cases,1.47%).The most common route of administration that induced ADR was intravenous drip,followed by oral administration.ADR involved organs and (or) systems mainly performed as skin and append ages disorders,followed by digestive system and circulatory system.Conclusion:The occurrence of ADR was related to various clinical factors,the medical institutions are suppose to strengthen the monitoring on ADR,improve the cooperation between clinicians and drugs and actively play the role of clinical pharmacists so as to promote the rational drug application in clinic.

关 键 词：药物相关性副作用和不良反应 药物副反应报告系统 处方不当 合理用药 

分 类 号：R95[医药卫生—药学]