High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure  

作　　者：Tengjiao Zhu Hufei Wang Zehao Jing Daoyang Fan Zhongjun Liu Xing Wang Yun Tian 

机构地区：[1]Department of Orthopaedics,Peking University Third Hospital,Beijing,100191,China [2]Beijing Key Laboratory of Spinal Disease Research,Beijing,100191,China [3]Engineering Research Center of Bone and Joint Precision Medicine,Ministry of Education,Beijing,100191,China [4]Beijing National Laboratory for Molecular Sciences,Institute of Chemistry,Chinese Academy of Sciences,Beijing,100190,China [5]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Bioactive Materials》2022年第2期12-19,共8页生物活性材料（英文）

基　　金：supported by the Ministry of Science and Technology of the People’s Republic of China(2018YFE0104200);National Natural Science Foundation of China(51873214,51973226,81871782 and 82002030);the Youth Innovation Promotion Association CAS(No.2019031)for financial support.

摘　　要：Advances in meticulous dural closure technique remain a great challenge for watertight dural closure in the aged society,because the cerebrospinal fluid(CSF)leakage after spinal surgery is often accompanied with the disgusting wound infection,meningitis and pseudomeningocele.Here,a tetra-poly(ethylene glycol)(PEG)-based hydrogel sealant is developed with collective advantages of facile operation,high safety,quick set time,easy injectability,favorable mechanical strength and powerful tissue adhesion for effective sutureless dural closure during the surgery procedure.Impressively,this tetra-PEG sealant can instantaneously adhere to the irregular tissue surfaces even in a liquid environment,and effectively prevent or block off the intraoperative CSF leakage for sutureless dural closure and dura regeneration.Together,this sutureless tetra-PEG adhesive can be utilized as a very promising alternative for high-efficient watertight dural closure of the clinical patients who incidentally or deliberately undergo the durotomy during the spinal surgery.

关 键 词：CSF leakage Dural repair Watertight closure SUTURELESS Tetra-PEG hydrogel 

分 类 号：TQ427.26[化学工程]