Antimicrobial properties of dental cements modified with zein-coated magnesium oxide nanoparticles  

作　　者：Ghada H.Naguib Hani M.Nassar Mohamed T.Hamed 

机构地区：[1]Department of Restorative Dentistry,Faculty of Dentistry,King Abdulaziz University,Jeddah,Saudi Arabia [2]Department of Oral Biology,Faculty of Dentistry,Cairo University,Cairo,Egypt [3]Department of Oral and Maxillofacial Prosthodontics,King Abdulaziz University,Faculty of Dentistry,Jeddah,Saudi Arabia [4]Department of Fixed Prosthodontics,Faculty of Dentistry,Cairo University,Cairo,Egypt

出　　处：《Bioactive Materials》2022年第2期49-56,共8页生物活性材料（英文）

基　　金：funded by Deanship of Scientific Research(DSR),King Abdulaziz University,Jeddah,Saudi Arabia,under grant No.(DF-044-165-1441).

摘　　要：The aim of this study was to test the antimicrobial properties of dental cements modified with magnesium oxide(MgO)nanoparticles.Zein-modified MgO nanoparticles(zMgO)in concentrations(0.0,0.3,0.5,and 1.0%)were mixed with dental cements(Fuji II,Rely X Temp E,Ionoglass Cem,Es Temp NE,and System P link).Eight discs were fabricated from each zMgO-cement pair for a total of 32 specimens for each cement.Characterization of the dental cements incorporating zMgO was done by X-ray Diffraction(XRD)and Field Emission Scanning Electron Microscopy(FESEM).The antimicrobial properties of the mixtures were tested using direct contact and agar diffusion assays against Streptococcus mutans,Staphylococcus aureus,Enterococcus faecalis,and Candida albicans.Data was analyzed using two-way analysis of variance and LSD post hoc test at 0.05 significance level.XRD spectra showed sharp peaks of zMgO indicating its high crystalline nature,while the amorphous dental cements with zMgO had broad peaks.FESEM analysis showed a uniform distribution of the zMgO nanoparticles in the cement.There were significant inhibition zone values associated with all concentrations of zMgO-cement mixtures tested compared to controls(p<0.001)with a dose-response recorded only with Fuji II.Optical density values were significantly lower in zMgO groups compared to controls for all microorganisms.The effect was most prominent with Rely X against C.albicans and S.aureus.Dental cements containing zMgO showed significant antimicrobial properties that were dependent on the specific initial cement substrate.

关 键 词：Magnesium oxide nanoparticles Antimicrobial biomaterials Dental cement NANOCOATINGS 

分 类 号：R318[医药卫生—生物医学工程] TB383[医药卫生—基础医学]