Hierarchical ultrastructure:An overview of what is known about tendons and future perspective for tendon engineering  

作　　者：Shichen Zhang Wei Ju Xiaoyi Chen Yanyan Zhao Lingchong Feng Zi Yin Xiao Chen 

机构地区：[1]Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine and Department of Orthopedic Surgery of the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,310052,China [2]Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province,School of Medicine,Zhejiang University,Hangzhou,310058,China [3]Guangxi Key Laboratory of Regenerative Medicine,Guangxi-ASEAN Collaborative Innovation Center for Major Disease Prevention and Treatment,Guangxi Medical University,Guangxi,530021,China [4]State Key Laboratory of Clean Energy Utilization,Zhejiang University,Hangzhou,310058,Zhejiang,China [5]Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine and Regenerative Medicine and Department of Orthopedic Surgery of Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou,310058,China [6]Department of Sports Medicine,School of Medicine,Zhejiang University,Hangzhou,310058,China [7]China Orthopedic Regenerative Medicine Group(CORMed),Hangzhou,310058,China

出　　处：《Bioactive Materials》2022年第2期124-139,共16页生物活性材料（英文）

基　　金：supported by the National Key Research and Development Program of China(2018YFC1105100);NSFC grants(81772418,81972099,81871764,82072463);Zhejiang Provincial Natural Science Foundation of China(LR20H060001);Fundamental Research Funds for the Central Universities.

摘　　要：Abnormal tendons are rarely ever repaired to the natural structure and morphology of normal tendons.To better guide the repair and regeneration of injured tendons through a tissue engineering method,it is necessary to have insights into the internal morphology,organization,and composition of natural tendons.This review summarized recent researches on the structure and function of the extracellular matrix(ECM)components of tendons and highlight the application of multiple detection methodologies concerning the structure of ECMs.In addition,we look forward to the future of multi-dimensional biomaterial design methods and the potential of structural repair for tendon ECM components.In addition,focus is placed on the macro to micro detection methods for tendons,and current techniques for evaluating the extracellular matrix of tendons at the micro level are introduced in detail.Finally,emphasis is given to future extracellular matrix detection methods,as well as to how future efforts could concentrate on fabricating the biomimetic tendons.

关 键 词：TENDON Collagen fibrillogenesis Extracellular matrix FIB-SEM Biomimetic 

分 类 号：R318[医药卫生—生物医学工程]