Gelatin-based composite hydrogels with biomimetic lubrication and sustained drug release  

作　　者：Kuan ZHANG Jielai YANG Yulong SUN Yi WANG Jing LIANG Jing LUO Wenguo CUI Lianfu DENG Xiangyang XU Bo WANG Hongyu ZHANG 

机构地区：[1]State Key Laboratory of Tribology,Department of Mechanical Engineering,Tsinghua University,Beijing 100084,China [2]School of Chemical and Biological Engineering,Shandong University of Science and Technology,Qingdao 266590,China [3]Department of Orthopedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [4]Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopaedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [5]Beijing Research Institute of Automationfor Machinery Industry Co.,Ltd.,Beijing 100120,China

出　　处：《Friction》2022年第2期232-246,共15页摩擦（英文版）

基　　金：This study was financially supported by the National Natural Science Foundation of China(Nos.51675296,21868011,and 81772372);Shanghai Municipal Science Foundation(No.SYXF011803);Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program(No.20191080593);the National Key R&D Program of China(No.2017YFC1103800);Foshan-Tsinghua Innovation SpecialFund(FTISF);Research Fund of State Key Laboratoryof Tribology,Tsinghua University,China(No.SKLT-2020C11);and Ng Teng Fong Charitable Foundation(No.202-276-132-13).

摘　　要：The occurrence of osteoarthritis is closely related to progressive and irreversible destruction of the articular cartilage,which increases the friction significantly and causes further inflammation of the joint.Thus,a scaffold for articular cartilage defects should be developed via lubrication restoration and drug intervention.In this study,we successfully synthesized gelatin-based composite hydrogels,namely GelMA–PAM–PMPC,with the properties of biomimetic lubrication and sustained drug release by photopolymerization of methacrylic anhydride modified gelatin(GelMA),acrylamide(AM),and 2-methacryloyloxyethyl phosphorylcholine(MPC).Tribological test showed that the composite hydrogels remarkably enhanced lubrication due to the hydration lubrication mechanism,where a tenacious hydration shell was formed around the zwitterionic phosphocholine headgroups.In addition,drug release test indicated that the composite hydrogels efficiently encapsulated an anti-inflammatory drug(diclofenac sodium)and achieved sustained release.Furthermore,the in vitro test revealed that the composite hydrogels were biocompatible,and the mRNA expression of both anabolic and catabolic genes of the articular cartilage was suitably regulated.This indicated that the composite hydrogels could effectively protect chondrocytes from inflammatory cytokine-induced degeneration.In summary,the composite hydrogels that provide biomimetic hydration lubrication and sustained local drug release represent a promising scaffold for cartilage defects in the treatment of osteoarthritis.

关 键 词：HYDROGEL articular cartilage zwitterionic polymer hydration lubrication drug delivery 

分 类 号：TQ427.26[化学工程] TQ460.4