肌肉量和密度与握力及起立-行走测试的相关性研究  

The associations of muscle size and density with handgrip strength and timed up and go test

作　　者：孙薇 刘艳东 李玉玲 冯秀芳 王浩 刘晓姗 刘国才 贾红燕 李建业 陈硕 尹潞 张萍[4] 程晓光[2] 王玲[2] Sun Wei;Liu Yandong;Li Yuling;Feng Xiufang;Wang Hao;Liu Xiaoshan;Liu Guocai;Jia Hongyan;JianyeShuo;Yin Lu;Zhang Ping;Cheng Xiaoguang;Wang Ling(Xinjiekou Community Health Service Center,Beijing 100035 China;Department of Radiology,Beijing Jishuitan Hospital,Beijing 100035,China;Medical Research&Biometrics Center,National Center for Cardiovascular Disease»Beijing 102300,China;Department of Cadre Healthcare,Beijing Jishuitan Hospital,Beijing 100035,China)

机构地区：[1]北京市西城区新街口社区卫生服务中心,北京100035 [2]北京积水潭医院放射科,北京100035 [3]国家心血管中心医学研究与生物信息中心,北京102300 [4]北京积水潭医院干部科,北京100035

出　　处：《中华老年医学杂志》2022年第4期406-410,共5页Chinese Journal of Geriatrics

基　　金：国家自然科学基金青年项目(81901718)。

摘　　要：目的 旨在比较肌肉密度(肌肉质量)和肌肉大小(肌量)与起立-行走测试及握力的相关性.方法 招募北京积水潭医院附近新街口社区的301名老年志愿者.所有研究对象均行髋部CT检查及大腿中段1 cm层厚的CT扫描.用Osirix软件体质分析模块分别测量髋部臀大肌和大腿中段的肌肉面积和密度.完成握力和起立-行走测试(TUG).运用Logistic回归分析比较肌肉密度和大小与TUG和握力的相关性.结果 校正年龄和BMI后,女性臀大肌密度与TUG呈负相关(Ptrend=0.0366),而女性臀大肌大小及大腿中段肌肉大小均与TUG无关;对于男性,各个肌肉密度和大小均与TUG无关.校正年龄和BMI后,男性臀大肌密度与握力呈正相关(Ptrend=0.0334),而大腿中段肌肉大小与握力也呈正相关(Ptrend=0.0155);对于女性,各个肌肉密度和大小均与握力无关.结论 肌肉大小和密度与握力及起立行走测试的关系存在性别差异,臀大肌的肌肉密度与肌力和躯体功能相关,而大腿中段肌肉大小与肌力相关.Objective The aim of this study was to explore the associations of muscle size and density with handgrip strength(HGS)and the Timed Up and Go(TUG)test.Methods Totally 301 participants living in the Xinjiekou community near B&jing Jishuitan Hospital were recruited for CT imaging of the hip and a 1-cm slice of the mid-thigh.The cross-sectional area and density of the gluteus maximus and the mid-thigh muscles were estimated by the Osirix viewer based on CT images.HGS and TUG were also performed in these subjects.Logistic regression analysis was used to evaluate the correlations of muscle density and size with TUG and grip strength.Results In women,after adjustment for age and BMI,the density of the gluteus maximus was negatively correlated with TUG(P trend=0.0366)»while the size of the gluteus maximus and the mid-thigh muscles was not correlated with TUG.In men»the density or size of these muscles was not correlated with TUG.After adjustment for age and BMI,the density of the gluteus maximus was positively correlated with grip strength(P trend=0.0334)and the size of the mid-thigh muscles was also positively correlated with grip strength(P trend=Q.0155)in men,but they were not correlated with grip strength in women.Conclusions There were sex differences in the relationship between muscle size or density and grip strength or timed up and go.The density of the gluteus maximus is associated with muscle strength and physical performance while the size of the mid-thigh muscles is correlated with muscle strength.

关 键 词：肌肉大小 肌肉密度 握力 躯体功能 

分 类 号：R685[医药卫生—骨科学]