补肾活血贴在老年气阴两虚挟瘀证糖尿病肾脏疾病中的应用  

Application and efficiency of kidney-helping and blood-activating paste in senile diabetic kidney disease of Qi-Yin Deficiency Syndrome

作　　者：周玉琴[1] 徐亚青[1] 郑建娣[1] 陈芳芳 郑宋宋 Zhou Yuqin;Xu Yaqing;Zheng Jiandi;Chen Fangfiing;Zhang Sonsojig(Zhe jicing Hospital of Integrated Traditional Chinese and Western Medicine»Hangzhou 310003,China)

机构地区：[1]浙江省中西医结合医院内分泌科,杭州310003

出　　处：《中华老年医学杂志》2022年第4期456-459,共4页Chinese Journal of Geriatrics

基　　金：浙江省中医药科技计划项目(2020ZB184)。

摘　　要：目的观察补肾活血贴在老年气阴两虚挟瘀证糖尿病肾脏疾病受试者中的应用效果.方法采用随机对照的研究方法,纳入2020年2月至2021年5月在浙江省中西医结合医院内分泌科就诊的100例老年气阴两虚挟瘀证的糖尿病肾脏疾病患者,数字抽签随机分为观察组50例(1例因皮肤破损终止试验)和对照组50例(3例转科终止试验).观察组患者给予补肾活血贴联合中医定向透药治疗仪治疗10 d,对照组给予安慰剂贴联合中医定向透药治疗仪治疗10 d,观察患者的主要症状记分及总体的证候积分和尿白蛋白肌酐比值.结果治疗后观察组较对照组患者的症状记分[口干咽燥(0.06±0.24)分比(0.30±0.68)分]、自觉劳累[(0.49±0.76)分比(0.98±1.02)分]、自汗或动则汗出[(0.08±0.27)分比(0.32±0.69)分]、肢体麻木[(0.49±0.64)分比(0.83±0.93)分]、小便不畅[(0.20±0.53)分比(0.55±0.92)分]和总证候积分[(1.65±2.06)分比(3.36±2.53)分]低,差异有统计学意义(均P<0.05);慢性肾脏病A2期观察组(20例)尿白蛋白肌酐比值下降有效率的平均Ridit值为0.595,高于对照组(20例)的0.405,两组比较差异有统计学意义(P<0.05).结论补肾活血贴可改善老年糖尿病肾脏疾病患者的临床症状,对改善早期糖尿病肾脏疾病患者的尿白蛋白肌酐比值可能有一定作用,值得临床推广应用.Objeetive To observe the application and efficiency of Bushen Huoxue Plaster in senile subjects with diabetic kidney disease with Qi Yin Deficiency with Blood stasis.Methods A total of 100 elderly diabetic kidney disease(DKD)patients with Qi Yin deficiency and Blood stasis syndrome in Endocrinology Department of Zhejiang Province Traditional Chinese and Western Medicine Hospital from February 2020 to May 202 lwere randomly divided into observation group(n=50)receiving TonifyingKidney and Activating Blood Paste plus TCM directional drug penetration therapy instrument for 10 days and control group(n=50)receiving placebo paste plus TCM directional drug penetration therapy instrument for 10 d.Main symptom score,overall syndrome score,urinary albumin/creatinine ratio were observed and recorded.Results After treatment,the observation group versus the control groups showed the statistically significant improvement in dry mouth and pharynx[(0.06±0.24)versus(O.30±0.68)]score point.in feeling tired[(0.49±0.76)versus(0.98±1.02)score point].in spontancous sweating or sweating after exercise[(0.08±0.27)us.(0.32±0.69)score point].in limb numbness[(0.49±0.64)us.(0.83±0.93)score point],in urination obstruction[(0.20±0.53)us.(0.55±0.92)score point].and in total syndrome score[(1.65±2.06)us.(3.36±2.53)score point,(all P<0.05)].The mean Ridit value of urinary albumin/creatinine ratio decreased in the observation group of chronic kidney disease stage A2 was 0.595 being higher than 0.405 in the control group,and the difference was statistically significant(P<0.05).Conclusions The kidney-helping and blood-activating paste can improve the clinical symptoms of senile patients,and may have a certain effect on improving the urine albumin/creatinine ratio of patients with early diabetic kidney disease»and it is worthy of clinical application.

关 键 词：气阴两虚 糖尿病肾病 补肾活血贴 

分 类 号：R259[医药卫生—中西医结合] R277.5[医药卫生—中医内科学]