微生物产色素机制及其生物活性  

Production mechanism and biological activity of microbial pigments

作　　者：于雪 张威 吴玉洁 陈拓 刘光琇 YU Xue;ZHANG Wei;WU Yujie;CHEN Tuo;LIU Guangxiu(Key Laboratory of Desert and Desertification,Northwest Institute of Eco-Environment and Resources,Chinese Academy of Sciences,Lanzhou 730000,Gansu,China;Key Laboratory of Extreme Environmental Microbial Resources and Engineering,Northwest Institute of Eco-Environment and Resources,Chinese Academy of Sciences,Lanzhou 730000,Gansu,China;State Key Laboratory of Cryospheric Science,Northwest Institute of Eco-Environment and Resources,Chinese Academy of Sciences,Lanzhou 730000,Gansu,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院西北生态环境资源研究院,沙漠与沙漠化重点实验室,甘肃兰州730000 [2]中国科学院西北生态环境资源研究院,甘肃省极端环境微生物资源与工程重点实验室,甘肃兰州730000 [3]中国科学院西北生态环境资源研究院,冰冻圈科学国家重点实验室,甘肃兰州730000 [4]中国科学院大学,北京100049

出　　处：《微生物学报》2022年第4期1231-1246,共16页Acta Microbiologica Sinica

基　　金：国家重点研发计划政府间国际科技创新合作专项(2019YFE0121100);国家自然科学基金(31870479);甘肃省科技计划(18JR2TA019,20YF3WA007)。

摘　　要：近年来,随着人工合成色素的大量使用引起一系列环境和健康问题,增加了人们对安全、无毒天然色素的需求。天然色素主要来源于植物和微生物,由于植物生长周期较长使植物源色素在大规模应用中受限。与植物源天然色素相比,微生物源色素易于大规模快速培养,具有更广阔的应用前景。本文系统总结了不同微生物源色素产生机制,及其在抗菌、抗氧化及抗癌等生物医药领域的研究进展,并对其面临的问题及未来的发展进行了展望。The environmental and health problems caused by the massive use of synthetic pigments in recent years increase the demand for safe,non-toxic natural pigments.Natural pigments are mainly derived from plants and microorganisms.However,the large-scale application of plant-derived pigments is limited by the long growth cycle of plants.Compared with plants,microorganisms are easy to be cultivated on a large scale in a short time and thus microorganism-derived pigments have a broad application prospect.We systematically summarized the production mechanisms,reviewed the research progress in the antibacterial,anti-oxidation and anti-cancer activities,and put forward the opportunities and challenges in the development of microorganism-derived pigments.

关 键 词：微生物 色素 生物合成机制 生态适应机制 生物活性 

分 类 号：Q936[生物学—微生物学]