苯并咪唑在单溶剂固液相平衡中的热力学  

Thermodynamic on corresponding solid-liquid equilibrium of benzimidazole in pure organic solvents

作　　者：原元 潘英敏 朱凤梅 吴伟 戴明明 陈登云 李祥鹏 吴刚 YUAN Yuan;PAN Ying-min;ZHU Feng-mei;WU Wei;DAI Ming-ming;CHEN Deng-yun;LI Xiang-peng;WU Gang(Nanjing Chia Tai Tianqing Pharmaceutical Co.,Ltd.,Nanjing 210038,Jiangsu Province,China)

机构地区：[1]南京正大天晴制药有限公司,江苏南京210038

出　　处：《化学工程》2022年第2期48-53,共6页Chemical Engineering(China)

摘　　要：苯并咪唑的固液平衡数据对于工业应用的初步研究至关重要。文中通过质量法研究了常压状态、温度5—55℃(278.15—328.15 K)下苯并咪唑在水、甲醇、乙醇、丙酮、乙腈、乙酸乙酯、二甲基甲酰胺和四氢呋喃纯溶剂中的固液平衡情况。将溶解度数据经过改进的Apelblat模型、Buchowski-Ksiazaczakλh模型和理想模型3种模型拟合分析。计算结果表明,改进的Apelblat模型因与测量值有较小的平均偏差而优于其他模型。此外,计算的热力学参数表明,在所研究的每种溶剂中,苯并咪唑的溶解都是吸热、非自发和焓驱动的过程。The thermodynamic parameters on corresponding solid-liquid equilibrium of benzimidazole in different solvents are essential for a preliminary study of pharmaceutical engineering and industrial applications.A mass method was used to correct the solid-liquid equilibrium of benzimidazole in water,methanol,ethanol,acetone,acetonitrile,ethyl acetate,dimethylformamide and tetrahydrofuran pure solvents in the temperatures(from 278.15 to 328.15 K)under 0.1 MPa.For the temperature range investigation,the solubility of benzimidazole in the solvents increased with increasing temperature.The solubility of benzimidazole in ethanol is superior to other selected pure solvents.The modified Apelblat model,the Buchowski-Ksiazaczakλh model,and the ideal model were adopted to describe and predict the change tendency of solubility.Computational results showed that the modified Apelblat model stood out to be more suitable with the higher accuracy.In addition,the calculated thermodynamic parameters indicated that in each studied solvents the dissolution of benzimidazole is endothermic,non-spontaneous and entropy-drive process.

关 键 词：苯并咪唑 Apelblat模型 Buchowski-Ksiazaczakλh模型 理想模型 热力学参数 

分 类 号：O645.12[理学—物理化学]