Nanocellulose,a versatile platform:From the delivery of active molecules to tissue engineering applications  被引量:2

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作  者:Tejal V.Patil Dinesh K.Patel Sayan Deb Dutta Keya Ganguly Tuhin Subhra Santra Ki-Taek Lim 

机构地区:[1]Department of Biosystems Engineering,Institute of Forest Science,Kangwon National University,Chuncheon,24341,Republic of Korea [2]Interdisciplinary Program in Smart Agriculture,Kangwon National University,Chuncheon,24341,Republic of Korea [3]Deptarment of Engineering Design,Indian Institute of Technology,Madras,600036,India

出  处:《Bioactive Materials》2022年第3期566-589,共24页生物活性材料(英文)

基  金:This research was supported by the Basic Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(NRF-2018R1A6A1A03025582);and the National Research Foundation of Korea(NRF-2019R1D1A3A03103828).

摘  要:Nanocellulose,a biopolymer,has received wide attention from researchers owing to its superior physicochemical properties,such as high mechanical strength,low density,biodegradability,and biocompatibility.Nanocellulose can be extracted from wide range of sources,including plants,bacteria,and algae.Depending on the extraction process and dimensions(diameter and length),they are categorized into three main types:cellulose nanocrystals(CNCs),cellulose nanofibrils(CNFs),and bacterial nanocellulose(BNC).CNCs are a highly crystalline and needle-like structure,whereas CNFs have both amorphous and crystalline regions in their network.BNC is the purest form of nanocellulose.The nanocellulose properties can be tuned by chemical functionalization,which increases its applicability in biomedical applications.This review highlights the fabrication of different surface-modified nanocellulose to deliver active molecules,such as drugs,proteins,and plasmids.Nanocellulose-mediated delivery of active molecules is profoundly affected by its topographical structure and the interaction between the loaded molecules and nanocellulose.The applications of nanocellulose and its composites in tissue engineering have been discussed.Finally,the review is concluded with further opportunities and challenges in nanocellulose-mediated delivery of active molecules.

关 键 词:NANOCELLULOSE Chemical functionalization Drug delivery Protein delivery Plasmid delivery Tissue engineering 

分 类 号:R318.08[医药卫生—生物医学工程] TB332[医药卫生—基础医学]

 

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