Surface treatment of 3D printed porous Ti6Al4V implants by ultraviolet photofunctionalization for improved osseointegration  

作　　者：Chuan Yin Teng Zhang Qingguang Wei Hong Cai Yan Cheng Yun Tian Huijie Leng Caimei Wang Shiqing Feng Zhongjun Liu 

机构地区：[1]Department of Orthopedics,Peking University Third Hospital,Beijing,100191,People’s Republic of China [2]Department of Orthopedics,Qilu Hospital of Shandong University,Jinan,250012,People’s Republic of China [3]Center for Biomedical Materials and Tissue Engineering,Academy for Advanced Interdisciplinary Studies,Peking University,Beijing,100871,People’s Republic of China [4]Beijing AKEC Medical Company Ltd.,Beijing,102200,People’s Republic of China

出　　处：《Bioactive Materials》2022年第1期26-38,共13页生物活性材料（英文）

基　　金：The authors acknowledge the grant from the Ministry of Science and Technology of the People’s Republic of China(grant number 2016YFB1101501);Beijing Municipal Science&Technology Commission(Project Z181100001718195).Teng Zhang was supported in part by the Postdoctoral Fellowship of Peking-Tsinghua Center for Life Sciences.We also received research and financial support from the Beijing AKEC Medical Co.,Ltd.

摘　　要：Three-dimensional(3D)-printed porous Ti6Al4V implants play an important role in the reconstruction of bone defects.However,its osseointegration capacity needs to be further improved,and related methods are inadequate,especially lacking customized surface treatment technology.Consequently,we aimed to design an omnidirectional radiator based on ultraviolet(UV)photofunctionalization for the surface treatment of 3D-printed porous Ti6Al4V implants,and studied its osseointegration promotion effects in vitro and in vivo,while elucidating related mechanisms.Following UV treatment,the porous Ti6Al4V scaffolds exhibited significantly improved hydrophilicity,cytocompatibility,and alkaline phosphatase activity,while preserving their original mechanical properties.The increased osteointegration strength was further proven using a rabbit condyle defect model in vivo,in which UV treatment exhibited a high efficiency in the osteointegration enhancement of porous Ti6Al4V scaffolds by increasing bone ingrowth(BI),the bone-implant contact ratio(BICR),and the mineralized/osteoid bone ratio.The advantages of UV treatment for 3D-printed porous Ti6Al4V implants using the omnidirectional radiator in the study were as follows:1)it can significantly improve the osseointegration capacity of porous titanium implants despite the blocking out of UV rays by the porous structure;2)it can evenly treat the surface of porous implants while preserving their original topography or other morphological features;and 3)it is an easy-to-operate low-cost process,making it worthy of wide clinical application.

关 键 词：Three-dimensional-printed porous implants UV photofunctionalization Omnidirectional UV radiator OSSEOINTEGRATION 

分 类 号：R68[医药卫生—骨科学]