中药生姜的临方炮制及其精准用药分析  

Analysis on Prescription-based Processing and Precise Medication of Ginger

作　　者：康冰亚[1,3,4] 张辉 董鹏永[2] 张璐 朱晓丽 陈天朝[1,3,4] KANG Bingya;ZHANG Hui;DONG Pengyong;ZHANG Lu;ZHU Xiaoli;CHEN Tianchao(Department of Pharmacy,the First Affiliated Hospital of Henan University of Chinese Medicine,Henan Zhengzhou 450000,China;Information Department,the First Affiliated Hospital of Henan University of Chinese Medicine,Henan Zhengzhou 450000,China;Henan Engineering Laboratory of Clinical Evaluation Technology of Traditional Chinese Medicine,Henan Zhengzhou 450000,China;Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry of P.R.China,Henan University of Chinese Medicine,Henan Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院药学部,河南郑州450000 [2]河南中医药大学第一附属医院信息科,河南郑州450000 [3]中药临床评价技术河南省工程实验室,河南郑州450000 [4]河南中医药大学呼吸疾病中医药防治省部共建协同创新中心,河南郑州450000

出　　处：《中国医药导刊》2022年第3期258-262,共5页Chinese Journal of Medicinal Guide

基　　金：国家中医药管理局中药炮制技术传承基地项目(项目编号:国中医药规财发[2015]21号,项目名称:河南省中药炮制技术传承基地);河南省中医药管理局国家中医临床研究基地科研专项(项目编号:2019JDZX2057,项目名称:朱清山老药工炮制经验传承的数字化、可视化研究);河南省中医药科学研究专项课题(项目编号:20-21ZY2171,项目名称:基于真实世界雷公藤多苷片临床应用的风险/效益评估)。

摘　　要：目的:以生姜为研究载体,分析中药生姜的临方炮制品种姜炭及煨姜在临床上的精准用药,为临床合理用药提供参考依据。方法:检索中国知网、万方数据库等国内外相关文献数据库,整理生姜及其临方炮制品的相关文献,并从炮制方法、炮制前后化学成分变化及临床精准用药三方面的研究概况进行分析。结果:生姜、姜炭及煨姜经不同方法炮制后,主要药效成分挥发油及姜辣素成分差异较大,如生姜、姜炭挥发油中姜烯含量分别为22.59%和29.13%。不同学者采用相同提取方法所得的主要药效成分含量差异亦较大,如姜炭姜辣素中的6-姜酚含量检测值分别为4.75 mg·g^(-1)和0.90 mg·g^(-1)。化学成分含量差异决定了药理作用的不同,进而影响临床疗效。结论:临方炮制方法有必要制定统一的技术标准,标准的临方炮制品种可弥补常规炮制品种的单一,满足临床用药的需求。Objective:To analyze the clinical precise medication of ginger charcoal and simmered ginger,which are the prescription-based processing varieties of ginger,so as to provide reference basis for clinical rational drug use.Methods:Based on the relevant full-text databases at home and abroad,such as CNKI,Wanfang Data,etc.,the relevant literatures on ginger and its prescription-based processing varieties were sorted out,and the research overview was analyzed and summarized from the aspects of processing methods,changes of chemical components before and after processing and clinical precise medication.Results:After processed by different methods,there were great differences in the components of volatile oil and gingerol in ginger,ginger charcoal and simmered ginger.For example,the content of zingiberene in volatile oil was 22.59% in ginger and 29.13% in ginger charcoal.The components obtained by the same extraction method also differ greatly among different scholars.For example,the content of 6-gingerol in gingerol in ginger charcoal was 4.75 mg·g^(-1) and 0.90 mg·g^(-1) respectively.The difference in the content of chemical components determines the different pharmacological effects,and will affect the clinical curative effect.Conclusion:It is necessary to formulate unified technical standards for the prescription-based processing methods.The standard prescription-based processing varieties can make up for the limited conventional processing varieties and meet the needs of clinical medication.

关 键 词：生姜 姜炭 煨姜 临方炮制 精准用药 

分 类 号：R283.1[医药卫生—中药学]