MRI表观扩散系数直方图参数在新生儿缺氧缺血性脑病预后评估中的应用价值  

The Application Value of MRI Apparent Diffusion Coefficient Histogram Parameters in the Prognostic Evaluation of Neonatal Hypoxic-Ischemic Encephalopathy

作　　者：王铁锋[1] 高玉冰 WANG Tie-feng;GAO Yu-bing(Department of Neonatal,Zhoukou City Central Hospital,Zhoukou 466000,Henan Province,China)

机构地区：[1]周口市中心医院新生儿科,河南周口466000

出　　处：《罕少疾病杂志》2022年第5期38-41,共4页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨磁共振成像(MRI)表观扩散系数(ADC)直方图参数在新生儿缺氧缺血性脑病(HIE)预后评估中的应用价值。方法选定本院2019年1月至2021年1月收诊的90例HIE患儿纳入试验组,同期选择40例无神经系统症状体征的新生儿作为对照组,其中按照疾病严重程度将试验组患儿分为试验1组(50例,中重度HIE)、试验2组(40例,轻度HIE)。观察两组的10%~90%ADC值、最大ADC值(ADC_(max))、最小ADC值(ADC_(min))、平均ADC值(ADC_(mean)),同时比较试验组间的10%~90%ADC值、ADC_(max)值、ADC_(min)值、ADC_(mean)值,并分析上述指标与新生儿行为神经评分(NBNA)是否存在相关性。结果试验组的10%~90%ADC值、ADC_(max)值、ADC_(min)值、ADC_(mean)值,均较对照组高(P<0.05);试验1组的上述指标水平,均较试验2组高(P<0.05);NBNA评分<35分组的上述指标水平,均较NBNA评分≥35分组高(P<0.05)。试验组的10%~90%ADC值、ADC_(max)值、ADC_(min)值、ADC_(mean)值与NBNA评分存在正相关性(P<0.05)。结论MRI ADC直方图参数可用于反映HIE的疾病严重程度,同时一定程度上能够预测其预后状况。Objective To investigate the use of magnetic resonance imaging(MRI)apparent diffusion coefficient(ADC)histogram parameters in the prognostic evaluation of neonatal hypoxic-ischemic encephalopathy(HIE)Application value.Methods Ninety children with HIE admitted to our hospital from January 2019 to January 2021 were selected to be included in the experimental group.At the same time,40 neonates with no neurological symptoms and signs were selected as the control group.The trial was carried out according to the severity of the disease.The children in the group were divided into test group 1(50 cases,moderate to severe HIE)and test group 2(40 cases,mild HIE).Observe the 10%-90% ADC values,maximum ADC values(ADC_(max)),minimum ADC values(ADC_(min)),and mean ADC values(ADC_(mean))of the two groups,and compare the experimental groups at the same time 10%-90% ADC value,ADC_(max) value,ADC_(min) value,ADC_(mean) value between 10%-90%,and analyze whether there is a correlation between the above indicators and neonatal behavioral neurological assessment(NBNA).Results The 10%-90% ADC value,ADC_(max) value,ADC_(min) value,ADC_(mean) value of the experimental group were higher than those of the control group(P<0.05);The abovementioned index levels of the experimental group were higher than those of the experimental group 2(P<0.05);The above-mentioned index levels in the NBNA score<35 group were higher than those in the NBNA score≥35 group(P<0.05).The 10%-90% ADC value,ADC_(max) value,ADC_(min) value,ADC_(mean) value of the experimental group were positively correlated with the NBNA score(P<0.05).Conclusion MRI ADC histogram parameters can be used to reflect the severity of HIE,and at the same time can predict its prognosis to a certain extent.

关 键 词：新生儿缺氧缺血性脑病 MRI表观扩散系数直方图参数 预后评估 

分 类 号：R445.2[医药卫生—影像医学与核医学] R651.15[医药卫生—诊断学]