lncRNA在家畜脂肪细胞分化中的作用研究进展  

Research Progress on the Effects of lncRNA on Livestock Adipocyte Differentiation

作　　者：李鑫 王永[1] 王雨雪 李艳艳 朱江江 林亚秋 LI Xin;WANG Yong;WANG Yuxue;LI Yanyan;ZHU Jiangjiang;LIN Yaqiu(Key Laboratory of Ministry of Education,Sichuan Province for Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Exploitation,Sichuan Chengdu 610041,China;College of Animal Science&Veterinary Medicine,Southwest Minzu University,Sichuan Chengdu,610041,China)

机构地区：[1]青藏高原动物遗传资源保护与利用,四川省重点实验室,四川成都610041 [2]西南民族大学畜牧兽医学院,四川成都610041

出　　处：《中国畜牧杂志》2022年第4期59-64,共6页Chinese Journal of Animal Science

基　　金：国家自然科学基金项目(82002817);青藏高原动物遗传资源保护与利用四川省重点实验室(2020PTJS16)。

摘　　要：长链非编码RNA(long non-coding RNA,lncRNA)是一类具有较高组织细胞特异性、不具有编码功能的RNA片段,广泛参与各种生物反应过程。脂肪性状是肉用家畜的重要经济性状,其沉积部位和数量是影响肉质的重要因素。近些年研究表明lncRNA分别从转录、转录后和表观遗传等不同作用水平调控动物脂肪细胞分化。本文在概述lncRNA生物学特性的基础上,对家畜脂肪细胞分化相关的lncRNA及可能的作用机制研究进行综述,以期为构建动物脂肪细胞分化的调控网络提供参考。Long non-coding RNA(lncRNA) is a type of noncoding RNA fragment with high tissue-specificity and cellspecificity, which is widely involved in various biological processes. Fat traits are pivotal economic traits of meat-used livestock, and its deposition site and quantity are important factors affecting meat quality. In recent years, studies have shown that lncRNA regulates the differentiation of animal adipocytes through different biological process such as transcription,post-transcription and epigenetics. Based on an overview of the biological characteristics of lncRNA, this article reviewed the studies on lncRNA related to the differentiation of animal adipocytes and possible mechanisms of action, to provide a reference for constructing a regulatory network of animal adipocyte differentiation.

关 键 词：长链非编码RNA 脂肪细胞分化 调控网络 

分 类 号：S813.1[农业科学—畜牧学]