利心水方联合常规西药治疗冠心病心力衰竭的临床效果  

Clinical effects of Lixinshui Decoction combined with conventional Western medicine in the treatment of heart failure of coronary heart disease

作　　者：宋晓龙[1] 宋俊[1] 潘仁友 孙伟新[1] 伍德明[1] 倪其猛[1] SONG Xiaolong;SONG Jun;PAN Renyou;SUN Weixin;WU Deming;NI Qimeng(Department of Cardiology,Yancheng Hospital Affiliated to Nanjing University of Chinese Medicine,Jiangsu Province,Yancheng 210023,China)

机构地区：[1]南京中医药大学附属盐城医院心内科,江苏盐城224000

出　　处：《中国医药导报》2022年第11期68-72,共5页China Medical Herald

基　　金：江苏省中医药科技发展计划项目(YB201968);全国老中医药专家学术经验继承工作项目(国中医药办人教发〔2017〕29号)。

摘　　要：目的观察利心水方联合常规西药治疗冠心病心力衰竭的临床效果,以及对患者运动耐量、生活质量、N末端B型钠尿肽(NT-proBNP)及血管内皮生长因子(VEGF)的影响。方法收集南京中医药大学附属盐城医院2020年2月至12月收治的冠心病心力衰竭患者82例,根据随机数字表法将其分为对照组和治疗组,每组40例。两组均以常规西药作为基础治疗,治疗组加用利心水方,两组疗程均为12周。观察两组临床疗效、中医证候积分、左室射血分数(LVEF)、明尼苏达州心力衰竭生命质量调查表(MLHFQ)评分、6 min步行试验(6MWT)距离、NT-proBNP、VEGF。记录两组治疗期间不良反应发生情况。结果治疗组中脱落2例(1例失访,1例胃肠不适退出),对照组脱落1例(失访),本研究最终纳入79例患者。治疗组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组各项中医证候积分均优于治疗前,治疗组气短、畏寒肢冷、唇甲青紫、乏力的中医证候积分优于对照组,差异有统计学意义(P<0.05)。治疗后,两组MLHFQ评分、NT-proBNP均低于治疗前,6MWT距离、LVEF、VEGF均高于治疗前,且治疗组MLHFQ评分、NT-proBNP均低于对照组,6MWT距离、LVEF、VEGF均高于对照组,差异有统计学意义(P<0.05)。两组治疗期间无不良反应发生。结论利心水方联合常规西药治疗冠心病心力衰竭疗效确切,能提高患者运动耐量及心功能,改善生活质量,对促进血管新生有一定作用。Objective To observe the clinical effects of Lixinshui Decoction combined with conventional Western medicine in the treatment of heart failure of coronary heart disease,and the effects of exercise tolerance,quality of life,N-terminal B-type natriuretic peptide(NT-proBNP),and vascular endothelial growth factor(VEGF)in patients.Methods A total of 82 coronary heart disease patients with heart failure admitted to Yancheng Hospital Affiliated to Nanjing University of Chinese Medicine from February to December 2020 were divided into control group and treatment group according to random number table method,with 40 patients in each group.Both groups were treated with conventional Western medicine as the basic treatment,the treatment group was treated with Lixinshui Decoction,the course of treatment in both groups was 12 weeks.Clinical efficacy,traditional Chinese medicine syndrome score,left ventricular ejection fraction(LVEF),Minnesota living with heart failure questionnaire(MLHFQ),6-minute walking test(6MWT)distance,NT-proBNP,and VEGF were observed in both groups.The incidence of adverse reactions during treatment was recorded.Results There were two cases of detachment in the treatment group(one case of loss of follow-up,one case of gastrointestinal discomfort)and one case of detachment in the control group(loss of follow-up).A total of 79 patients were eventually included in this study.The clinical efficacy of the treatment group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the traditional Chinese medicine syndromes scores in both groups were better than before,and the traditional Chinese medicine syndromes scores of shortness of breath,fear of cold and cold hand and foot,cyanotic lips and nails,malaise in the treatment group were better than those in the control group,and the differences were statistically significant(P<0.05).After treatment,MLHFQ scores and NT-proBNP in both groups were lower than those before the treatment,6MWT distance,LVEF,and

关 键 词：利心水方 冠心病 心力衰竭 生活质量 

分 类 号：R541.4[医药卫生—心血管疾病]