湿润烧伤膏治疗Ⅱ度热力烧伤患者的效果  

The effect of moisture exposed burn ointment in the treatment of second-degree thermal burns

作　　者：张盼盼 张琳 ZHANG Panpan;ZHANG Lin(Hebi People's Hospital,Hebi 458030,Henan)

机构地区：[1]鹤壁市人民医院,河南鹤壁458030

出　　处：《菏泽医学专科学校学报》2022年第1期11-14,共4页Journal of Heze Medical College

摘　　要：目的探讨Ⅱ度热力烧伤患者采用湿润烧伤膏的治疗效果,分析其对创面血管内皮生长因子(VEGF)、转化生长因子-β1(TGF-β1)的影响。方法选择我院收治的105例Ⅱ度烧伤患者,随机数字表法分为观察组和对照组。两组患者入院后均接受创面清洗、防感染、预防破伤风、补液、营养支持治疗等基础处理,对照组52例患者在清创后涂抹磺胺嘧啶银乳膏,观察组53例患者在清创后涂抹湿润烧伤膏治疗,比较两组患者炎性因子水平[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)以及白介素-6(IL-6)]、生长因子水平[血管内皮生长因子(VEGF)、转化生长因子-β1(TGF-β1)以及碱性成纤维细胞生长因子(bFGF)]、创面愈合时间、VSS评分。结果治疗前两组患者炎性因子水平比较,P>0.05;治疗后,观察组TNF-α、hs-CRP以及IL-6均低于对照组(P<0.05);治疗前两组患者生长因子水平比较,P>0.05;治疗后观察组VEGF、TGF-β1以及bFGF均高于对照组(P<0.05);观察组创面愈合时间短于对照组,VSS评分均低于对照组(P<0.05)。结论湿润烧伤膏治疗Ⅱ度热力烧伤患者效果显著,尤其在减轻创面炎症反应、促进创面愈合、提高愈合程度等方面优于磺胺嘧啶银乳膏。Objective To explore the effect of moisture exposed burn ointment(MEBO)in the treatment of second-degree thermal burns,and to analyze its effect on wound vascular endothelial growth factor(VEGF)and transforming growth factor-β1(TGF-β1).Methods 105 patients with second-degree burns in our department were randomly divided into the control group and the observation group.After admission,both the two groups received basic treatments such as wound cleaning,infection prevention,tetanus prevention,fluid infusion,and nutritional support treatment.52 cases in the control group received silver sulfadiazine cream,and 53 cases in the observation group were treated with MEBO.The inflammatory factors levels[tumor necrosis factor-α(TNF-α),hypersensitivity C reaction protein(hs-CRP)and interleukin-6(IL-6)],growth factor levels[vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1)and basic fibroblast growth factor(bFGF)],wound healing time and VSS scores were compared between the two groups.Results There was no significant difference in the levels of inflammatory factors between the two groups before treatment(P>0.05);after treatment,the TNF-α,hs-CRP and IL-6 levels in the observation group were lower than those of the control group(P<0.05).There was no significant difference in the growth factor levels between the two groups before treatment(P>0.05);after treatment,the VEGF,TGF-β1 and bFGF levels in the observation group were higher than those of the control group(P<0.05).The wound healing time of the observation group was shorter than that of the control group,and the VSS scores were lower than those of the control group (P <0.05). Conclusion MEBO is effective in treating second-degree thermal burn, especially in reducing wound inflammation, promoting wound healing, and improving the degree of healing, which is worthy of recommending.

关 键 词：湿润烧伤膏 热力烧伤 疗效 

分 类 号：R751[医药卫生—皮肤病学与性病学]