终末期良性肝病肝移植受者预后评分系统的研究进展  

Review of risk evaluation scores for benign end stage liver diseases recipients

作　　者：金平波 王卫利 章云涛[1] 马楠[1] 白雪莉[1] 张微[1] 梁廷波[1] Jin Pingbo;Wang Weili;Zhang Yuntao;Ma Nan;Bai Xueli;Zhang Wei;Liang Tingbo(Department of Hepatic-biliary-pancreatic Surgery,First Affiliated Hospital of Zhejiang University,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第一医院肝胆胰外科,杭州310003

出　　处：《中华外科杂志》2022年第4期396-400,共5页Chinese Journal of Surgery

摘　　要：肝移植术是挽救终末期良性肝病患者的重要手段,评估终末期良性肝病患者等待期和移植术后生存情况可更精确地指导供器官分配。近年来提出的终末期良性肝病相关的预后评分系统可分为两大类。一类基于终末期肝病模型(MELD)评分系统,包括SOFT评分、P-SOFT评分、UCLA-FRS评分和BAR评分;另一类评分系统基于慢加急性肝功能衰竭概念,包括CLIF-C-ACLF评分、TAM评分、AARC-ACLF评分和COSSH-ACLF评分。基于慢加急性肝功能衰竭概念的评分较MELD评分在预测终末期肝病患者等待期和肝移植术后预后中展现出更优异的效能。本文总结回顾了这两类评分系统优缺点,探讨更合理的器官分配模式,以期提高终末期良性肝病患者的整体预后。Liver transplant is an unreplaceable method for benign end-stage liver disease.The risk evaluation for the waiting list recipients and for post-transplant survival could provide practical indication for organ allocation.In recent years,there are two major kinds of evaluation scores.The first kind of evaluation scores is based on model for end-stage liver disease(MELD)score,including SOFT/P-SOFT score,UCLA-FRS score and BAR score.The other evaluation system is based on the concept of acute-on-chronic liver failure,including CLIF-C-ACLF score,TAM score,AARC-ACLF score and COSSH-ACLF score.The scores based on ACLF have been shown superior power in predicting waiting list survival and post-transplant prognosis than MELD.This article reviews the two kinds of evaluation scores,aiming for the better allocation policy and the better prognosis of benign end-stage liver disease.

关 键 词：肝移植 肝疾病 预后评价模型 慢加急性肝功能衰竭 器官分配 

分 类 号：R657.3[医药卫生—外科学]