肝素结合蛋白分子特性及其与感染性疾病关系研究进展  

Molecular features of heparin-binding protein and its relationship with infectious diseases

作　　者：李荔 冯贵龙 牛争平 LI Li;FENG Gui-long;NIU Zheng-ping(Emergency Center,the First Clinical Medical College of Shanxi Medical University,Taiyuan,Shanxi 030001,China)

机构地区：[1]山西医科大学第一临床医学院急诊医学中心,山两太原030001

出　　处：《中华实用诊断与治疗杂志》2022年第4期418-421,共4页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家临床重点专科建设项目(国卫办医函[2013]544号)。

摘　　要：肝素结合蛋白在抗菌、促进炎性反应及调节内皮细胞通透性中发挥重要作用,对感染和脓毒症的早期诊断有重要意义。肝素结合蛋白既是单核细胞的化学引诱剂,也可诱导血管渗漏和水肿形成,其被释放后发挥抗菌特性并对免疫系统产生影响,对早期感染性疾病的诊断具有一定价值。本文就肝素结合蛋白特性及其与感染性疾病关系的研究进展作一综述。Heparin-binding protein(HBP) plays an important role in antibiosis, promoting inflammatory response and regulating endothelial cell permeability, and has an important clinical significance for the early diagnosis of infection and sepsis. Being a chemical inducer of monocytes, HBP also can induce vascular leakage and edema formation. After release, HBP exerts antibacterial properties and has significant subsequent effects on the immune system, which has a certain predictive value to the early diagnosis of infectious diseases. This paper reviews the research progress of the features of HBP and its relationship with infectious diseases.

关 键 词：感染性疾病 脓毒症 肝素结合蛋白 炎症 

分 类 号：R459.7[医药卫生—急诊医学]