肺移植缺血再灌注损伤研究进展  

Ischemia-reperfusion injury in lung transplantation

作　　者：孟凡若 姚文健 张全 李基伟 魏立 MENG Fan-ruo;YAO Wen-jian;ZHANG Quan;LI Ji-wei;WEI Li(Department of Thoracic Surgery,Henan University People's Hospital,Henan Provincial People's Hospital,ZhengzhouHenan 450003,China)

机构地区：[1]河南大学人民医院河南省人民医院胸外科,河南郑州450003

出　　处：《中华实用诊断与治疗杂志》2022年第4期422-424,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200021)。

摘　　要：肺移植是治疗特发性肺纤维化、特发性肺动脉高压、慢性阻塞性肺疾病及支气管扩张等终末期肺病的有效方法,但肺移植后易发生缺血再灌注损伤、原发性移植物功能障碍等并发症,严重影响患者预后。本文就肺移植术后缺血再灌注损伤发生的病理生理机制及治疗方法的研究进展作一综述。Lung transplantation is an effective method for end-stage lung diseases such as idiopathic pulmonary fibrosis, idiopathic pulmonary hypertension, chronic obstructive pulmonary disease and bronchiectasis, but the complications often develop as ischemia-reperfusion injury and primary graft dysfunction after lung transplantation, which seriously affect the prognosis of patients. This paper reviews the research progress of the pathophysiological mechanism and treatment of ischemia-reperfusion injury after lung transplantation.

关 键 词：肺移植 缺血再灌注损伤 炎症 内皮保护 体外肺灌注 

分 类 号：R655.3[医药卫生—外科学]