妊娠期高血压患者PECAM-1 LRRFIP PagT表达及预测子痫前期的ROC分析  

The Expression of PECAM-1 LRRFIP PagT in Patients with Gestational Hypertension and the ROC Analysis of Predicting Preeclampsia

作　　者：李燕茹 LI Yanru(Kunming First People's Hospital, Yunnan Kunming 650000, China)

机构地区：[1]云南省昆明市第一人民医院产科,云南昆明650000

出　　处：《河北医学》2022年第4期589-593,共5页Hebei Medicine

基　　金：云南省科技厅课题计划,(编号:202001BA070001-014)。

摘　　要：目的:探讨妊娠期高血压(GH)患者血小板内皮细胞黏附分子1(PECAM-1)、富亮氨酸重复序列相互作用蛋白(LRRFIP)、血小板聚集率(PagT)表达及预测子痫前期(PE)的价值。方法:选取2018年4月至2021年2月我院收治的93例GH患者,根据病情进展情况分为子痫组(n=22)、PE组(n=31)、GH组(n=40),并选取同期正常孕妇35例作为对照组。比较各组基线资料、PECAM-1、LRRFIP、PagT、收缩压、舒张压、尿蛋白定量,应用Pearson分析PECAM-1、LRRFIP、PagT与收缩压、舒张压、尿蛋白定量关系,采用多因素Logistic回归方程分析PE及子痫的相关影响因素,采用受试者工作特征曲线(ROC)及ROC下面积(AUC)分析PECAM-1、LRRFIP、PagT预测PE及子痫的价值。结果:PECAM-1:子痫组<PE组<GH组<对照组,LRRFIP、PagT、收缩压、舒张压、尿蛋白定量:子痫组>PE组>GH组>对照组(P<0.05);PECAM-1与收缩压、舒张压、尿蛋白定量呈负相关,LRRFIP、PagT与收缩压、舒张压、尿蛋白定量呈正相关(P<0.05);将收缩压、舒张压、尿蛋白定量控制后,PECAM-1、LRRFIP、PagT仍与PE及子痫的发生相关(P<0.05);预测PE的AUC:PECAM-1为0.723,LRRFIP为0.761,PagT为0.682,三者联合为0.804;预测子痫的AUC:PECAM-1为0.777,LRRFIP为0.779,PagT为0.735,三者联合为0.850。结论:GH患者PECAM-1、LRRFIP、PagT表达与PE、子痫的发生有关,联合检测可作为预测PE及子痫的有效方案,为临床提供参考。Objective:To investigate the expression of platelet endothelial cell adhesion molecule 1(PECAM-1),leucine-rich repeat interacting protein(LRRFIP),and platelet aggregation rate(PagT),and to investigate the value in predicting preeclampsia(PE),in patients with Gestational hypertension(GH).Methods:A total of 93 GH patients admitted to our hospital from April 2018 to February 2021 were selected and divided into eclampsia group(n=22),PE group(n=31),and GH group(n=40)according to the progress of the disease.And 35 healthy pregnant women were made the control group.The baseline data of each group,PECAM-1,LRRFIP,PagT,systolic blood pressure,diastolic blood pressure,and urine protein quantification were compared;Pearson was used to analyze the quantitative relationship between PECAM-1,LRRFIP,PagT and systolic blood pressure,diastolic blood pressure,and urine protein;multi-factor Logistic regression equation was used to analyze the related factors of PE and eclampsia;the receiver operating characteristic curve(ROC)and area under ROC(AUC)were used to analyze the value of PECAM-1,LRRFIP,and PagT in predicting PE and eclampsia.Results:PECAM-1:eclampsia group<PE group<GH group<control group;LRRFIP,PagT,systolic blood pressure,diastolic blood pressure,urine protein quantification:eclampsia group>PE group>GH group>control group(P<0.05);PECAM-1 is negatively correlated with systolic blood pressure,diastolic blood pressure,and urine protein quantification.LRRFIP and PagT are positively correlated with systolic blood pressure,diastolic blood pressure,and urine protein quantification(P<0.05).After the systolic blood pressure,diastolic blood pressure,and urine protein quantification are controlled,PECAM-1,LRRFIP,PagT are still related to the occurrence of PE and eclampsia(P<0.05).Predictors of AUC of PE:PECAM-1 is 0.723,LRRFIP is 0.761,PagT is 0.682,the combination of the three is 0.804;predictors of AUC of epilepsy:PECAM-1 is 0.777,LRRFIP is 0.779,PagT is 0.735,and the combination of the three is 0.850.Conclusion:The expressions of

关 键 词：妊娠期高血压 血小板内皮细胞黏附分子1 富亮氨酸重复序列相互作用蛋白 血小板聚集率 子痫前期 子痫 

分 类 号：R71[医药卫生—妇产科学]