合成MRI与传统定量方法对T1、T2弛豫值测定的模体验证对比研究  

A comparative study on phantom verification of T1 and T2 relaxation values determined by synthetic MRI and conventional mapping methods

作　　者：刘雅文 牛海军[1,2] 尹红霞[3] 郑作锋[4] 任鹏玲 张婷婷 赵鹏飞[3] 吕晗[3] 王振常[1,2,3] LIU Yawen;NIU Haijun;YIN Hongxia;ZHENG Zuofeng;REN Pengling;ZHANG Tingting;ZHAO Pengfei;LÜHan;WANG Zhenchang(School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China;Beijing Advanced Innovation Center for Biomedical Engineering,Beihang University,Beijing 100191,China;Department of Radiology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Radiology,Beijing Chuiyangliu Hospital,Beijing 100022,China)

机构地区：[1]北京航空航天大学生物与医学工程学院,北京100191 [2]北京航空航天大学生物医学工程高精尖创新中心,北京100191 [3]首都医科大学附属北京友谊医院放射科,北京100050 [4]北京市垂杨柳医院放射科,北京100022

出　　处：《磁共振成像》2022年第4期89-93,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金重点项目(编号:61931013);北京学者(京人社专家发[2015]160号)。

摘　　要：目的通过与传统定量方法进行对比,验证合成MRI对纵向弛豫时间(longitudinal relaxation time,T1)、横向弛豫时间(transverse relaxation time,T2)定量计算的准确性及可重复性。材料与方法针对3.0 T MRI设备,使用灰质、白质、脑脊液模体分别进行合成MRI序列和传统定量成像扫描,共进行四次重复采集。对传统定量图像,通过拟合计算方法得到相应的T1、T2值;对合成MRI图像,使用专用后处理软件计算T1、T2值。对两种方法得到的定量值进行差值计算和重复测量方差分析。结果合成MRI和传统定量方法计算的T1值之间差异无统计学意义(F=0.113,P=0.7537),并且四次测量之间差异无统计学意义(F=0.613,P=0.4968);同样地,两种方法计算的T2值之间差异无统计学意义(F=0.001,P=0.9737),四次测量之间差异无统计学意义(F=1.162,P=0.3498)。结论合成MRI对T1、T2弛豫定量测定结果准确,可应用于临床中的定量研究。Objective:To verify the accuracy and repeatability of the quantitative imaging of longitudinal relaxation time(T1)and transverse relaxation time(T2)relaxation in synthetic MRI.Materials and Methods:For a 3.0 T MR device,three phantoms of gray matter,white matter and cerebrospinal fluid were respectively scanned by synthetic MRI and conventional quantitative magnetic resonance imaging(qMRI),and the acquisition was repeated four times.For conventional qMRI,the corresponding T1 and T2 values were obtained by fitting calculation,while for synthetic MRI,the T1 and T2 values were calculated using MAGiC software.Two-way analysis of variance was used to compare phantom values obtained by synthetic MRI and those calculated by conventional mapping methods.Results:The results of analysis of variance of T1and T2 showed that there are no significant difference between the synthetic MRI and conventional qMRI(F=0.113,P=0.7537 and F=0.001,P=0.9737,respectively).For either method,there was no significant difference at different time points(F=0.613,P=0.4968 and F=1.162,P=0.3498,respectively).Conclusions:The relaxation quantitative calculation results of T1 and T2 under the synthetic MRI are accurate,which is conducive to clinical application.

关 键 词：定量磁共振成像 合成磁共振成像 模体验证 脑部疾病 

分 类 号：R445.2[医药卫生—影像医学与核医学]