DCE-MRI联合CA125、CA153对肺部良恶性肿块/结节鉴别效能及意义  

The Efficacy and Significance of DCEMRI Combined with CA125 and CA153 in Distinguishing Benign and Malignant Masses/Nodules in the Lungs

作　　者：杨安妮 黎泳娥 洪荣臻 YANG An-ni;LI Yong-e;HONG Rong-zhen(Department of Radiology,tongji Hospital,tongji Medical College,Huazhong University of Science and technology,Wuhan 430030,Hubei Province,China;Department of Cardiology,tongji Hospital,tongji Medical College,Huazhong University of Science and technology,Wuhan 430030,Hubei Province,China)

机构地区：[1]华中科技大学同济医学院附属同济医院放射科,湖北武汉430030 [2]华中科技大学同济医学院附属同济医院心内科,湖北武汉430030

出　　处：《中国CT和MRI杂志》2022年第5期57-60,共4页Chinese Journal of CT and MRI

基　　金：国家自然科学基金(81601507)。

摘　　要：目的分析动态增强磁共振成像(DCE-MRI)联合血清糖类抗原CA125、CA153对肺部良恶性肿块/结节鉴别效能及意义。方法选取我院肺部肿块/结节患者159例,根据病理活检结果分为恶性组(n=106)与良性组(n=53)。病理活检前均接受DCEMRI检查、血清CA125、CA153水平检测,比较两组及恶性组不同病理特征患者DCE-MRI定量参数(K^(trans)、K_(ep))、血清CA125、CA153水平,评估DCEMRI定量参数、血清CA125、CA153与恶性组病理特征的相关性及对肺部良恶性肿块/结节的鉴别效能。结果恶性组容量转移常数(K^(trans))、速率常数(K_(ep))、血清CA125、CA153水平高于良性组(P<0.05);K^(trans)、K_(ep)、血清CA125、CA153与恶性组临床病理特征有关(P<0.05);K^(trans)、K_(ep)、血清CA125、CA153联合鉴别肺部良恶性肿块/结节的曲线下面积(AUC)最大。结论DCE-MRI定量参数联合血清CA125、CA153可为临床鉴别肺部良恶性肿块/结节、判断评估恶性病变病理特征提供循证支持。Objective To analyze the efficacy and significance of dynamic enhanced magnetic resonance imaging(DCE-MRI)combined with serum carbohydrate antigens CA125 and CA153 in distinguishing benign and malignant lung masses/nodules.Methods A total of 159 patients with lung masses/nodules in our hospital were selected and divided into malignant group(n=106)and benign group(n=53)according to the results of pathological biopsy.Before pathological biopsy,DCE-MRI examination and serum CA125 and CA153 levels were detected.The DCE-MRI quantitative parameters(K^(trans),Kep)and serum CA125 and CA153 levels of patients with different pathological characteristics in the two groups and malignant groups were compared,and the DCE-MRI quantitative parameters were evaluated.Correlation between serum CA125,CA153 and pathological characteristics of malignant group and the distinguishing power of benign and malignant lung masses/nodules.Results The volume transfer constant(K^(trans)),rate constant(K_(ep)),serum CA125 and CA153 levels of the malignant group were higher than those of the benign group(P<0.05);K^(trans),K_(ep),serum CA125,and CA153 were related to the clinicopathological characteristics of the malignant group(P<0.05);The area under the curve(AUC)of the combination of K^(trans),K_(ep),serum CA125,and CA153 in the identification of benign and malignant lung masses/nodules is the largest.Conclusion The combination of DCE-MRI quantitative parameters and serum CA125 and CA153 can provide evidence-based support for the clinical identification of benign and malignant pulmonary masses/nodules,as well as for evaluating the pathological characteristics of malignant lesions.

关 键 词：动态增强磁共振成像 糖类抗原CA125 糖类抗原CA153 肺部肿块/结节 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.35[医药卫生—诊断学]