枸橼酸咖啡因不同使用时机对机械通气早产儿氧疗时间及拔管后呼吸暂停的影响  

Effect of different timing of caffeine citrate use on the time of oxygen therapy in preterm infants with mechanical ventilation and apnea after extubation

作　　者：邹博群 ZOU Boqun(Department of Neonatology,Jiujiang Maternal and Child Health Hospital,Jiujiang,Jiangxi,332000,China)

机构地区：[1]九江市妇幼保健院新生儿科,江西九江332000

出　　处：《当代医学》2022年第12期74-76,共3页Contemporary Medicine

摘　　要：目的探讨枸橼酸咖啡因不同使用时机对机械通气早产儿氧疗时间及拔管后呼吸暂停的影响。方法选取2018年4月至2020年4月本院收治的68例机械通气早产儿作为研究对象,按照随机数字表法分为两组,每组34例。对照组于出生72 h后、撤呼吸机24 h内予以枸橼酸咖啡因治疗,观察组24~72 h内给予枸橼酸咖啡因治疗。比较两组氧疗时间、用药时间、呼吸暂停发生率、并发症发生率及不良反应发生率。结果观察组机械通气时间、持续气道正压通气(CPAP)时间、需氧时间和咖啡因使用时间分别为(7.14±1.16)d、(10.65±1.54)d、(19.55±2.04)d、(20.18±2.13)d,均短于对照组的(9.28±1.51)d、(12.41±1.68)d、(22.43±2.42)d、(24.36±2.28)d,差异有统计学意义(P<0.05);观察组呼吸暂停发生率、并发症发生率分别为5.88%、8.82%,均低于对照组的26.47%、29.41%,差异有统计学意义(P<0.05);两组均无严重不良反应。结论出生24~72 h予以枸橼酸咖啡因可缩短机械通气早产儿氧疗时间,减少呼吸暂停发生,降低并发症发生率,安全可靠,值得临床推广应用。Objective To explore the effects of different timing of caffeine citrate use on the duration of oxygen therapy in preterm infants with mechanical ventilation and apnea after extubation.Methods 68 preterm infants mechanically mechanical ventilation and apnea after extubation in our hospital from April 2018 to April 2020 were selected as the research subjects,and they were divided into two groups according to the random num-ber table method,with 34 cases in each group.The control group was given caffeine citrate therapy within 72 h after birth and within 24 h of the venti-lator withdrawal,while the observation group was given caffeine citrate therapy within 24-72 h.The oxygen therapy time,medication time,the inci-dence of apnea,the incidence of complications,and the incidence of adverse reactions were compared between the two groups.Results The mechani-cal ventilation time,continuous positive airway pressure(CPAP)time,aerobic time and caffeine use time in the observation group were(7.14±1.16)d,(10.65±1.54)d,(19.55±2.04)d,(20.18±2.13)d,which were shorter than([9.28±1.51]d,[12.41±1.68]d,[22.43±2.42]d,[24.36±2.28]d)in the control group,the difference was statistically significant(P<0.05).The incidence rates of the disease were 5.88%and 8.82%,which were lower than 26.47%and 29.41%in the control group,and the difference was statistically significant(P<0.05).There were no serious adverse reactions in the two groups.Conclusion Caffeine citrate 24-72 h after birth can shorten the oxygen therapy time,reduce the occurrence of apnea,and reduce the in-cidence of complications in mechanically ventilated premature infants,it is safe,reliable and worthy of clinical application.

关 键 词：呼吸暂停 机械通气 早产儿 枸橼酸咖啡因 氧疗时间 并发症 

分 类 号：R722.6[医药卫生—儿科]