维生素D2注射液联合抗生素对社区获得性肺炎患儿炎性因子和免疫功能的影响  

Effects of vitamin D2 combined with antibiotics on the inflammatory cytokines and immune function in children with community-acquired pneumonia

作　　者：代宝春 徐俊利 王雅坤[1] 赵利平 姜红[1] 张娟[1] 刘秀珍[1] 徐宝元[1] DAI Baochun;XU Junli;WANG Yakun(Handan Central Hospital,Hebei,Handan 056008,China;不详)

机构地区：[1]河北省邯郸市中心医院,056008 [2]河北省邯郸市第二医院

出　　处：《河北医药》2022年第7期1018-1021,共4页Hebei Medical Journal

基　　金：河北省卫健委医学科学研究课题计划项目(编号:20191853)。

摘　　要：目的研究维生素D2注射液联合抗生素对社区获得性肺炎(CAP)患儿炎性因子和免疫功能的影响。方法选取2019年10月至2020年10月收治的98例CAP患儿作为研究对象,随机分为对照组和联合组,每组49例。2组均给予抗炎、退热、化痰、止咳等常规治疗。联合组在对照组基础上补充维生素D2。比较2组炎性因子[白介素6(IL-6)、C-反应蛋白(CRP)、降钙素原(PCT)]、T淋巴细胞亚群(CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+))、NK、Th1/Th2及相关细胞因子、免疫球蛋白(IgG、IgA、IgM)、红细胞免疫指标(RBC-C3bR、RBC-ICR)变化。结果2组治疗前IL-6、CRP、PCT、CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)、NK、Th1、Th2、Th1/Th2、IFN-γ、IL-4、IFN-γ/IL-4、IgG、IgA、IgM、RBC-C3bR、RBC-ICR比较差异无统计学意义(P>0.05);2组治疗后IL-6、CRP、PCT、CD_(8)^(+)、Th2、IL-4、RBC-ICR均显著低于治疗前,CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)、NK、Th1、Th1/Th2、IFN-γ、IFN-γ/IL-4、IgG、IgA、IgM、RBC-C3bR均显著高于治疗前,差异有统计学意义(P<0.05),且联合组变化更明显,差异有统计学意义(P<0.05)。结论维生素D2注射液联合抗生素治疗CAP具有良好临床疗效,能够显著减轻炎性反应,增强细胞免疫、体液免疫和红细胞免疫功能。Objective To investigate the effects of vitamin D2 combined with antibiotics on the inflammatory cytokines and immune function in children with community-acquired pneumonia(CAP).Methods A total of 98 children with CAP who were treated in our hospital from October 2019 to October 2020 were enrolled in the study,who were randomly divided into control group(n=49)combination treatment group(n=49).The patients in both groups were treated by basic treatment including antiinfection,antipyretic,expectorant and relieving airway spasm,moreover,the patients in combination group were given vitamin D2.The levels of IL-6,CRP,PCT,CD_(3)^(+),CD_(4)^(+),CD_(8)^(+),NK,Th1/Th2 and related cytokines,IgG,IgA,IgM,RBC-C3bR and RBC-ICR before and after treatment were observed and compared between the two groups.Results Before treatment,there were no significant differences in the levels of IL-6,CRP,PCT,CD_(3)^(+),CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+),NK,Th1,Th2,Th1/Th2,IFN-γ,IL-4,IFN-γ/IL-4,IgG,IgA,IgM,RBC-C3bR and RBC-ICR between the two groups(P>0.05).After treatment,the levels of IL-6,CRP,PCT,CD_(8)^(+),Th2,IL-4 and RBC-ICR in both groups were significantly decreased,however,the levels of CD_(3)^(+),CD_(4)^(+),CD_(4)^(+)/CD_(8)^(+),NK,Th1,Th1/Th2,IFN-γ,IFN-γ/IL-4,IgG,IgA,IgM and RBC-C3bR were significantly increased(P<0.05),moreover,the decrease degree and increase degree in combination treatment group were more significant than those in control group(P<0.05).Conclusion The vitamin D2 combined with antibiotics in treatment of CAP has better curative effects,which can relieve inflammatory reaction,and improve the cellular immunity,humoral immunity and erythrocyte immune function of patients.

关 键 词：社区获得性肺炎 维生素D2 炎性因子 免疫功能 

分 类 号：R563.1[医药卫生—呼吸系统]