耳穴压籽联合穴位贴敷对晚期前列腺癌伴癌性疼痛患者血清疼痛介质的影响  被引量:1

Effect of auricular seed pressing combined with acupoint application on serum pain mediators of advanced prostate cancer patients with cancer pain

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作  者:汪利君[1,2] 韩子华 WANG Lijun;HAN Zihua(Department of Urology,Surgery Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University 317000,China;Department of Urology,Enze Hospital,Taizhou Enze Medical Center(Group),Taizhou 318050,China)

机构地区:[1]浙江省台州医院泌尿外科,浙江台州317000 [2]浙江省台州恩泽医疗中心(集团)恩泽医院泌尿科,浙江台州318050

出  处:《中国现代医生》2022年第7期98-101,共4页China Modern Doctor

基  金:浙江省医药卫生科技计划项目(2020KY1058)。

摘  要:目的探讨耳穴压籽联合穴位贴敷对晚期前列腺癌伴癌性疼痛患者血清疼痛介质的影响。方法选取2017年1月到2020年6月浙江省台州医院泌尿外科泌尿外科门诊就诊的晚期前列腺癌伴癌性疼痛患者70例,随机分为干预组和对照组,每组各35例。两组患者均予硫酸吗啡缓释片口服治疗。对照组患者予以穴位贴敷治疗,干预组患者在对照组基础上加耳穴压籽治疗,两组患者均连用2周。观察两组患者治疗前后疼痛评分、血清疼痛介质[5-羟色胺(5-HT)、去甲肾上腺素(NE)和前列腺素E_(2)(PG E_(2))]水平的变化,并比较其临床疗效。结果治疗2周后,干预组和对照组患者的VAS评分[(2.97±0.41)分、(4.15±0.67)分]均较前[(7.12±1.23)分、(7.09±1.08)分]明显下降(P<0.05或P<0.01),且观察组患者下降幅度较对照组更明显(P<0.05);干预组和对照组患者血清5-HT[(0.37±0.08)μmol/L、(0.49±0.10)μmol/L]、NE[(3.17±0.62)pg/ml、(4.28±0.82)pg/ml]和PGE_(2)[(86.54±13.23)pg/ml、(107.42±14.15)pg/ml]水平均较前[(0.64±0.13)μmol/L、(0.62±0.12)μmol/L、(5.60±1.03)pg/ml、(5.57±1.16)pg/ml、(147.65±20.71)pg/ml、(146.09±21.36)pg/ml]明显下降(P<0.05或P<0.01),且干预组患者下降幅度较对照组更明显(P<0.05);同时干预组患者临床总有效率(94.29%)明显优于对照组(77.14%),差异有统计学意义(χ^(2)=4.201,P<0.05)。结论耳穴压籽联合穴位贴敷治疗晚期前列腺癌伴癌性疼痛患者的疗效确切,能明显降低疼痛介质5-HT、NE和PGE_(2)水平,控制癌性疼痛的程度。Objective To explore the effect of auricular seed pressing combined with acupoint application on serum pain mediators of advanced prostate cancer patients with cancer pain.Methods A total of 70 patients with advanced prostate cancer and cancer pain who were treated in the Urology Clinic of Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University from January 2017 to June 2020 were selected and randomly divided into the intervention group and the control group,with 35 cases in each group.Both groups were treated with morphine sulfate sustained-release tablets orally.Patients in the control group were treated with acupoint application,and patients in the intervention group were treated with auricular seed pressing on the basis of the control group.Patients in both groups were treated for two weeks.The changes in the pain scores,serum pain mediators[5-hydroxytryptamine(5-HT),norepinephrine(NE),and prostaglandin E_(2)(PG E_(2))]levels before and after treatment were observed between the two groups of patients,and their clinical effects were compared.Results After two weeks of treatment,the VAS scores([2.97±0.41]points,[4.15±0.67]points)of the intervention group and the control group were significantly lower than those([7.12±1.23]points),(7.09±1.08)points]before(P<0.05 or P<0.01).The decline of patients in the intervention group was more significant than that in the control group(P<0.05).The serum 5-HT([0.37±0.08]μmol/L,[0.49±0.10]μmol/L),NE([3.17±0.62]pg/ml,[4.28±0.82]pg/ml)and PGE_(2)([86.54±13.23]pg/ml,[107.42±14.15]pg/ml)level in the intervention group and the control group were significantly lower than those before([0.64±0.13μ]mol/L,[0.62±0.12]μmol/L,[5.60±1.03]pg/ml,[5.57±1.16]pg/ml,[147.65±20.71]pg/ml,[146.09±21.36]pg/ml)(P<0.05 or P<0.01).And the decline in the intervention group was more significant than that in the control group(P<0.05).At the same time,the total effective rate of clinical patients in the intervention group(94.29%)was significantly better than that o

关 键 词:晚期前列腺癌 癌性疼痛 耳穴压籽 穴位敷贴 疼痛介质 

分 类 号:R245.9[医药卫生—针灸推拿学]

 

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