Multivalent network modifier upregulates bioactivity of multispecies biofilm-resistant polyalkenoate cement  

作　　者：Ji-Yeong Kim Woojin Choi Utkarsh Mangal Ji-Young Seo Tae-Yun Kang Joohee Lee Taeho Kim Jung-Yul Cha Kee-Joon Lee Kwang-Mahn Kim Jin-Man Kim Dohyun Kim Jae-Sung Kwon Jinkee Hong Sung-Hwan Choi 

机构地区：[1]Department of Orthodontics,Institute of Craniofacial Deformity,Yonsei University College of Dentistry,50-1 Yonsei-ro,Seodaemun-gu,Seoul 03722,Republic of Korea [2]BK21 FOUR Project,Yonsei University College of Dentistry,50-1 Yonsei-ro,Seodaemun-gu,Seoul 03722,Republic of Korea [3]Department of Chemical and Biomolecular Engineering,Yonsei University,50 Yonsei-ro,Seodaemun-gu,Seoul 03722,Republic of Korea [4]Department and Research Institute of Dental Biomaterials and Bioengineering,Yonsei University College of Dentistry,50-1 Yonsei-ro,Seodaemun-gu,Seoul 03722,Republic of Korea [5]Johns Hopkins University,3400 N.Charles St.,Mason Hall,Baltimore,MD 21218,USA [6]Department of Oral Microbiology and Immunology,School of Dentistry and Dental Research Institute,Seoul National University,Seoul 08826,Republic of Korea [7]Department of Conservative Dentistry,Oral Science Research Center,Yonsei University College of Dentistry,50-1 Yonsei-ro,Seodaemun-gu,Seoul 03722,Republic of Korea

出　　处：《Bioactive Materials》2022年第8期219-233,共15页生物活性材料（英文）

基　　金：supported by the Korea Medical Device Development Fund grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Trade,Industry and Energy,the Ministry of Health and Welfare,the Ministry of Food and Drug Safety)(Project Number:KMDF_PR_20200901_0067-01);by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.2021R1A2C2091260);by faculty research grant of Yonsei University College of Dentistry(6-2021-0037).

摘　　要：Polyalkenoate cement(PAC)is a promising material for regenerative hard tissue therapy.The ionically rich glass component of PAC encourages bioactive interaction via.the release of essential ions.However,PAC bioactivity is restricted owing to(i)structurally inherent cationic network formers and(ii)surface bacterial biofilm formation.These two factors cause a deficiency in ion release,further complicated by secondary infections and premature therapeutic failure.Here,a multivalent zwitterionic network modifier(mZM)is presented for upregulation of ionic exchange and bioactivity enhancement.By introducing a non-zero charged mZM into PACs,an increase in the proportion of non-bridging oxygen occurs.The network modification promotes ion channel formation,causing a multiple-fold increase in ion release and surface deposition of hydroxy-carbonate apatite(ca.74%).Experiments ex vivo and animal models also demonstrate the efficient remineralization ability of the mZM.Furthermore,divalent cationic interaction results in bacterial biofilm reduction(ca.68%)while also influencing a shift in the biofilm species composition,which favors commensal growth.Therefore,PAC modification with mZM offers a promising solution for upregulation of bioactivity,even aiding in customization by targeting site-specific regenerative therapy in future applications.

关 键 词：Multivalent network modifier Bioactive materials Glass polyalkenoate cement Ion release REMINERALIZATION Multispecies biofilm resistance 

分 类 号：R318[医药卫生—生物医学工程] TB3[医药卫生—基础医学]