Enhanced bone regenerative properties of calcium phosphate ceramic granules in rabbit posterolateral spinal fusion through a reduction of grain size  

作　　者：Xiangfeng Li Quan Zhou Yonghao Wu Cong Feng Xi Yang Linnan Wang Yumei Xiao Kai Zhang Xiangdong Zhu Limin Liu Yueming Song Xingdong Zhang 

机构地区：[1]National Engineering Research Center for Biomaterials,College of Biomedical Engineering,Sichuan University,Chengdu,610064,China [2]Department of Orthopaedic Surgery,West China Hospital of Sichuan University,Chengdu,610041,China

出　　处：《Bioactive Materials》2022年第5期90-106,共17页生物活性材料（英文）

基　　金：sponsored by the National Natural Science Foundation of China(52002256);Sichuan Science and Technology Innovation Team of China(2019JDTD0008);China Postdoctoral Innovation Talent Support program(BX20180204);China Postdoctoral Science Foundation(2018M643483);Sichuan University Postdoctoral Interdisciplinary Innovation Fund(0900904153024).

摘　　要：Osteoinductivity is a crucial factor to determine the success and efficiency of posterolateral spinal fusion(PLF)by employing calcium phosphate(Ca-P)bioceramics.In this study,three kinds of Ca-P ceramics with microscale to nanoscale gain size(BCP-control,BCP-micro and BCP-nano)were prepared and their physicochemical properties were characterized.BCP-nano had the spherical shape and nanoscale gain size,BCP-micro had the spherical shape and microscale gain size,and BCP-control(BAM®)had the irregular shape and microscale gain size.The obtained BCP-nano with specific nanotopography could well regulate in vitro protein adsorption and osteogenic differentiation of MC3T3 cells.In vivo rabbit PLF procedures further confirmed that nanotopography of BCP-nano might be responsible for the stronger bone regenerative ability comparing with BCP-micro and BCP-control.Collectedly,due to nanocrystal similarity with natural bone apatite,BCP-nano has excellent efficacy in guiding bone regeneration of PLF,and holds great potentials to become an alternative to standard bone grafts for future clinical applications.

关 键 词：Calcium phosphate ceramics NANOTOPOGRAPHY Osteogenic differentiation OSTEOINDUCTIVITY Posterolateral spinal fusion 

分 类 号：R318.08[医药卫生—生物医学工程] R68[医药卫生—基础医学]