Potential bioactive coating system for high-performance absorbable magnesium bone implants  

作　　者：Murni Nazira Sarian Nida Iqbal Pedram Sotoudehbagha Mehdi Razavi Qamar Uddin Ahmed Cortino Sukotjo Hendra Hermawan 

机构地区：[1]Institute of Systems Biology(INBIOSIS),Universiti Kebangsaan Malaysia,43600,Bandar Baru Bangi,Selangor,Malaysia [2]Bio-Medical Engineering Centre,University of Engineering&Technology Lahore,New Campus,Pakistan [3]BiionixTM(Bionic Materials,Implants&Interfaces)Cluster,Department of Internal Medicine,College of Medicine,University of Central Florida Health Sciences Campus at Lake Nona,6900 Lake Nona Blvd,Orlando,FL 32827,USA [4]Department of Pharmaceutical Chemistry,Kulliyyah of Pharmacy,International Islamic University Malaysia,25200,Kuantan DM,Pahang,Malaysia [5]Department of Restorative Dentistry,College of Dentistry,University of Illinois at Chicago,USA [6]Department of Mining,Metallurgical and Materials Engineering,Laval University,Quebec City,G1V 0A6,Canada

出　　处：《Bioactive Materials》2022年第6期42-63,共22页生物活性材料（英文）

基　　金：supported by the Universiti Kebangsaan Malaysia Research University Grant(GGPM-2020-037,MNS);the Natural Sciences and Engineering Research Council of Canada(RGPIN-2017-04274,HH).

摘　　要：Magnesium alloys are considered the most suitable absorbable metals for bone fracture fixation implants.The main challenge in absorbable magnesium alloys is their high corrosion/degradation rate that needs to be controlled.Various coatings have been applied to magnesium alloys to slow down their corrosion rates to match their corrosion rate to the regeneration rate of the bone fracture.In this review,a bioactive coating is proposed to slow down the corrosion rate of magnesium alloys and accelerate the bone fracture healing process.The main aim of the bioactive coatings is to enhance the direct attachment of living tissues and thereby facilitate osteoconduction.Hydroxyapatite,collagen type I,recombinant human bone morphogenetic proteins 2,simvastatin,zoledronate,and strontium are six bioactive agents that show high potential for developing a bioactive coating system for high-performance absorbable magnesium bone implants.In addition to coating,the substrate itself can be made bioactive by alloying magnesium with calcium,zinc,copper,and manganese that were found to promote bone regeneration.

关 键 词：Absorbable metals Bioactive agent Bone fracture COATING Magnesium alloys 

分 类 号：R318[医药卫生—生物医学工程]