PAF、HBD-2联合检测在PPROM合并绒毛膜羊膜炎患者中的诊断价值  

Diagnostic Value of Combined Detection of PAF and HBD-2 in the Patients with PPROM Complicated with Chorioamnionitis

作　　者：杨元晨 李娟[1] 王丽娟[1] 沈晓亚 YANG Yuanchen;LI Juan;WANG Lijuan;SHEN Xiaoya(Affiliated Nanjing Jiangbei Hospital of Nantong University,Nanjing 210048,China;不详)

机构地区：[1]南通大学附属南京江北医院,江苏南京210048

出　　处：《中外医学研究》2022年第9期55-58,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：江苏省南京市医学科技发展项目(YKK13183)。

摘　　要：目的:探究血小板活化因子(PAF)、人β防御素2(HBD-2)联合检测在未足月胎膜早破(PPROM)合并绒毛膜羊膜炎患者中的诊断价值。方法:选取南通大学附属南京江北医院2018年1月-2020年12月的108例PPROM患者为研究对象,将其根据产后胎盘胎膜病理检查结果分为A组(绒毛膜羊膜炎)50例和B组(非绒毛膜羊膜炎)58例,并选取同期的50例健康分娩孕妇为C组。比较三组血清PAF、HBD-2检测水平、单项及联合检测阳性率,同时比较PAF、HBD-2及联合检测对PPROM合并绒毛膜羊膜炎的特异度、灵敏度、阳性预测值及阴性预测值。结果:A组血清PAF、HBD-2检测水平,以及PAF、HBD-2单项及联合检测阳性率均显著高于B组及C组,B组显著高于C组,PAF联合HBD-2检测灵敏度及阴性预测值均显著高于单项PAF与HBD-2,差异有统计学意义(P<0.05)。结论:PAF、HBD-2联合检测在PPROM合并绒毛膜羊膜炎患者中的诊断价值较高。Objective:To investigate the diagnostic value of combined detection of platelet activating factor (PAF) and human beta-defensin 2 (HBD-2) in the patients with preterm premature rupture of membranes (PPROM) complicated with chorioamnionitis.Method:A total of 108 patients with PPROM from January 2018 to December 2020 in Affiliated Nanjing Jiangbei Hospital of Nantong University were chosen as study object,they were divided into group A (chorioamnionitis) 50 cases and group B (non chorioamnionitis) 58 cases according to the pathological examination results of postpartum placenta and fetal membrane,and 50 healthy delivery pregnant women at the same time were chosen as the group C.Then the serum PAF and HBD-2 levels,positive rates of single and combined detection of three groups were compared,and the specificity,sensitivity,positive predictive value and negative predictive value of PAF,HBD-2 and combined detection for PPROM complicated with chorioamnionitis were compared.Result:The serum PAF and HBD-2 levels,positive rates of single and combined detection of PAF,HBD-2 of group A were significantly higher than those of group B and group C,the results of group B were significantly higher than those of group C,and the sensitivity and negative predictive value of combined detection of PAF and HBD-2 were significantly higher than those of single PAF and HBD-2,there were statistically significant differences (P<0.05).Conclusion:The diagnostic value of combined detection of PAF and HBD-2 in the patients with PPROM complicated with chorioamnionitis is higher.

关 键 词：PAF HBD-2 联合检测 PPROM 绒毛膜羊膜炎 诊断价值 

分 类 号：R714.433[医药卫生—妇产科学]