谷氨酸脱氢酶作为药物性肝损伤潜在生物标志物的研究进展  

Research progress in glutamate dehydrogenase as potential circulating biomarkers of drug-induced liver injury

作　　者：黎韵 向怀荣 程旋 何贝 彭文兴[1,2] LI Yun;XIANG Huai-rong;CHENG Xuan;HE Bei;PENG Wen-xing(Department of Pharmacy,the Second Xiangya Hospital,Central South University,Changsha 410011,China;Institute of Clinical Pharmacy,Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院药学部,湖南长沙410011 [2]中南大学临床药学研究所,湖南长沙410011

出　　处：《中国药理学与毒理学杂志》2022年第3期206-210,共5页Chinese Journal of Pharmacology and Toxicology

摘　　要：药物性肝损伤(DILI)是常见的药物不良反应,可致急性肝衰竭或死亡等严重不良预后。早期、准确诊断DILI意义重大。传统生物标志物灵敏性与肝损伤特异性不足,寻找灵敏性更高、特异性更强的新型肝损伤生物标志物十分必要。谷氨酸脱氢酶(GLDH)是一种新型DILI生物标志物,比传统生物标志物的肝损伤特异性更强、灵敏性更高、稳定性更好。与其他新型生物标志物相比较,GLDH比miR-122的个体间和个体内差异小,比高迁移率族蛋白B1、骨桥蛋白和细胞角蛋白18的肝损伤特异性和灵敏性更好,且比这些新型生物标志物更易于检测,具有很好的临床应用前景。本文总结了传统生物标志物的不足,综述了GLDH作为DILI的潜在生物标志物的最新研究,以期全面了解GLDH作为DILI生物标志物的潜力。Drug-induced liver injury(DILI) is a common adverse drug reaction, which can cause serious adverse prognosis such as acute liver failure or death. Early and accurate diagnosis of DILI is of great significance. The sensitivity and specificity of traditional biomarkers for diagnosis of DILI are insufficient, making it necessary to find new biomarkers of liver injury with a higher sensitivity and specificity. Glutamate dehydrogenase(GLDH) is a new biomarker for the diagnosis of DILI. Current studies indicate that GLDH is more specific, sensitive and stable than traditional biomarkers for liver injury.GLDH shows smaller inter-individual and intra-individual differences than mi R-122, and manifests a better specificity and sensitivity to liver injury than high mobility group protein B1, osteopontin and cytokeratin18. In addition, the detection method of GLDH is simpler. Therefore, GLDH has good prospects of clinical application. This article summarizes the drewbacks of traditional biomarkers, and the latest research findings of GLDH as a potential biomarker of DILI in order to shed light on the potential of GLDH as a biomarker of DILI.

关 键 词：药物性肝损伤 谷氨酸脱氢酶 生物标志物 

分 类 号：R969[医药卫生—药理学]