2021年肾移植研究大盘点:来自中国的声音  

Research highlights on kidney transplantation in 2021:voices from China

作　　者：罗子寰 孙启全 Luo Zihuan;Sun Qiquan(Department of Kidney Transplantation,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China)

机构地区：[1]广东省医学科学院广东省人民医院肾移植科,广州510080

出　　处：《器官移植》2022年第3期325-332,共8页Organ Transplantation

基　　金：国家自然基金面上项目(82100797、81970650、81800663、81800661、81800662);国家重点研发计划项目(2018YFA0108804)。

摘　　要：经过近70年的发展,肾移植已成为所有器官移植手术里最成熟,也是成功率最高的手术,但肾移植相关缺血-再灌注损伤、排斥反应、慢性移植肾失功、移植肾纤维化、免疫抑制治疗与感染等仍是影响肾移植受者长期生存的关键因素,相关的基础与临床研究层出不穷。同时,在新型冠状病毒肺炎疫情常态化的背景下,与肾移植相关的研究也是一个新的热点。本文就2021年肾移植基础与临床相关的前沿热点以及肾移植相关的新技术、新视野做一综述,且介绍的研究以中国团队发表的报道为主,更符合中国肾移植的实际情况,以期为我国肾移植相关问题的诊疗提供新的思路和策略。Over the past 70 years,kidney transplantation has become not only the most mature but also the highest-success-rate surgery among all organ transplantation surgeries.However,the long-term survival of kidney transplant recipients is still challenged by such key factors as ischemia-reperfusion injury related to kidney transplantation,rejection,chronic renal allograft dysfunction,renal allograft fibrosis,immunosuppressive therapy,infections and others.Relevant fundamental and clinical studies have emerged endlessly.At the same time,the research related to kidney transplantation also becomes a new hot spot accordingly in the context of the normalization of novel coronavirus pneumonia.This article reviewed the cutting-edge hot spots in relation to the fundamental and clinical aspects of kidney transplantation together with relevant new techniques and new visions.The studies included in this article focused on the reports published by Chinese teams that are more applicable to the current situation of kidney transplantation in China,for the purpose of providing new thoughts and strategies for the diagnosis and treatment of kidney transplantation related issues in China.

关 键 词：肾移植 缺血-再灌注损伤 感染 免疫抑制剂 炎症反应 慢性移植肾失功 抗体介导的排斥反应 T细胞介导的排斥反应 

分 类 号：R617[医药卫生—外科学] R692[医药卫生—临床医学]