宫腔镜下子宫内膜息肉切除术联合地屈孕酮治疗子宫内膜息肉60例  

Hysteroscopic transcervical resection of polyps combined with dydrogesterone in the treatment of 60 cases of endometrial polyps

作　　者：刘艳 任娟 桑学梅[1] 吴霞[1] LIU Yan;REN Juan;SANG Xuemei;WU Xia(Department of Gynecology,General Hospital of Wanbei Coal and Electricity Group,Suzhou,Anhui 234000,China)

机构地区：[1]皖北煤电集团总医院妇科,安徽宿州234000

出　　处：《安徽医药》2022年第5期942-945,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的分析宫腔镜下子宫内膜息肉切除术(TCRP)联合地屈孕酮(达芙通)治疗子宫内膜息肉的疗效及对预后的影响。方法选取2015年1月至2018年11月皖北煤电集团总医院接收的子宫内膜息肉病人120例,据随机数表法分为两组,每组60例,对照组单行TCRP治疗,观察组行TCRP+地屈孕酮治疗,观察两组TCRP术后第12、18个月的月经量、血红蛋白、子宫内膜厚度、异常子宫出血情况以及第6、12、18个月子宫内膜息肉复发情况,并评估治疗效果。结果TCRP术后第12、18个月,观察组月经量[(42.63±6.81)比(64.06±5.75)分,(31.32±8.24)比(45.31±5.17)分]、子宫内膜厚度[(5.51±0.39)比(6.37±0.24)mm,(7.18±0.54)比(8.24±0.47)mm]、血红蛋白[(118.46±7.23)比(104.75±6.35)g/L,(134.59±7.29)比(119.26±7.83)g/L]及异常子宫出血[(18.33%比36.67%),(11.67%比30.00%)]与对照组相比,差异有统计学意义(P<0.05);观察组术后第6个月子宫内膜息肉复发率与对照组相比,差异无统计学意义(P>0.05),但第12、18个月子宫内膜息肉复发率[(6.67%比20.00%),(10.00%比28.33%)]与对照组相比,差异有统计学意义(P<0.05)。结论TCRP联合地屈孕酮可有效控制病人术后月经量及子宫内膜厚度,促进月经周期稳定,减少异常子宫出血,提高临床疗效,降低术后子宫内膜息肉复发率,是临床值得推广的一种治疗方案。Objective To analyze the efficacy of hysteroscopic transcervical resection of polyps(TCRP)combined with dydrogesterone(daphthone)in the treatment of endometrial polyps and its influence on prognosis.Methods A total of 120 patients with endometrial polyps received from the General Hospital of Wanbei Coal and Electricity Group from January 2015 to November 2018 were selected and divided into two groups according to the random number table method,with 60 cases in each group.The control group was treated with TCRP alone,and the observation group was treated with TCRP+dydrogesterone.The menstrual flow,hemoglobin,endometrial thickness,abnormal uterine bleeding and recurrence of endometrial polyps at the 6^(th),12^(th),and 18^(th) months after TCRP in the two groups were observed,and the treatment effect was evaluated.Results At the 12th and 18th months after TCRP,the menstrual flow[(42.63±6.81)vs.(64.06±5.75),(31.32±8.24)vs.(45.31±5.17)],endometrial thickness[(5.51±0.39)vs.(6.37±0.24)mm,(7.18±0.54)vs.(8.24±0.47)mm],hemoglobin[(118.46±7.23)vs.(104.75±6.35)g/L,(134.59±7.29)vs.(119.26±7.83)g/L],and abnormal uterine bleeding[(18.33%vs.36.67%),(11.67%vs.30.00%)]between the control group and the observation group were statistically significant(P<0.05).There was no significant difference in the recurrence rate of endometrial polyps between the observation group and the control group at the 6^(th) month after operation(P>0.05),but the recurrence rate of endometrial polyps[(6.67%vs.20.00%),(10.00%vs.28.33%)]at the 12^(th) and 18^(th) months was statistically significant compared with the control group(P<0.05).Conclusion TCRP combined with dydrogesterone can effectively control the postoperative menstrual flow and endometrial thickness of patients,promote the stability of the menstrual cycle,reduce abnormal uterine bleeding,improve clinical efficacy,and reduce the recurrence rate of endometrial polyps after surgery,which is worthy of clinical promotion.

关 键 词：息肉 子宫内膜 子宫内膜息肉 地屈孕酮 宫腔镜下子宫内膜息肉切除术 

分 类 号：R713.4[医药卫生—妇产科学]