特应性皮炎的转录组学研究进展  

Transcriptomics in atopic dermatitis

作　　者：覃诗纯 李梦杰 陆晓云 肖风丽[1] Qin Shichun;Li Mengjie;Lu Xiaoyun;Xiao Fengli(Department of Dermatology and Venereology,The First Affiliated Hospital of Anhui Medical University,Institute of Dermatology,Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学第一附属医院皮肤性病科安徽医科大学皮肤病研究所,合肥230022

出　　处：《中华皮肤科杂志》2022年第4期365-369,共5页Chinese Journal of Dermatology

基　　金：国家自然科学基金(81972926);安徽省学术和科技带头人科研活动经费资助项目(2017D141)。

摘　　要：随着基因芯片技术、RNA测序技术等转录组学技术发展, 特应性皮炎(AD)发病中重要的相关影响因素逐渐被揭示, 如不同T辅助(Th)细胞的亚型以及其他免疫相关细胞如巨噬细胞、朗格汉斯细胞;在AD的瘙痒及皮肤屏障破坏方面, 相关免疫细胞如Th2细胞及角质形成细胞等所释放白细胞介素4、白细胞介素13、聚丝蛋白、兜甲蛋白等活性物质的异常变化起着主要作用。同时, 转录组技术已被用于分析患者治疗前后转录谱的变化从而对患者的病情和治疗效果进行评估等。本文总结近年来在AD转录组学方面的研究进展。With the development of transcriptomic technologies such as gene chip technology and RNA sequencing technology,important related factors in the pathogenesis of atopic dermatitis(AD)have been gradually identified,such as different T helper(Th)cell subtypes and other immune-related cells(macrophages and Langerhans cells);abnormal changes in active substances such as interleukin-4,interleukin-13,fillagrin and loricrin released by immune-related cells such as Th2 cells and keratinocytes have been found to play major roles in pruritus and skin barrier damage in AD.In recent years,transcriptomic technologies have been applied to the analysis of changes in transcriptomic profiles of patients before and after treatment to evaluate patients′condition and therapeutic effect.This review summarizes research progress in transcriptomics in AD in recent years.

关 键 词：皮炎 特应性 转录组 芯片分析技术 RNA测序技术 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]