Toward Programming Bacterial Behavior via Synthetic Interfaces:Physicochemical Nanopatterning,Decoupling Surface Properties,and Integrating Material and Biological Insights  

作　　者：Yifan Cheng Rong Yang 

机构地区：[1]Department of Chemical and Biomolecular Engineering,Cornell University,Ithaca,New York 14853,United States

出　　处：《Accounts of Materials Research》2021年第11期979-985,共7页材料研究述评（英文）

基　　金：The authors thank the Office of Naval Research(ONR)for support through Award MURI N00014-20-1-2418 to R.Y.and through Award USDA NIFA 2021-67034-35040 to Y.C.

摘　　要：A.INTRODUCTION:FROM ANTIFOULING MATERIALS TO GREATER CONTROL OVER BACTERIAL BEHAVIOR Controlling the behavior of living organisms is a central topic in biomaterials design.Synthetic materials,empowered by rapid advances in surface engineering capabilities,present a highly programmable medium that may interface with living organisms in close proximity and gain broader control of the population via communal signaling.Interface-based control strategies are distinct from drugs and signals delivered via liquid phase and bring some unique advantages.For example,they help to reduce systemic side effects,enable targeted(and possibly more pronounced)effectuation,and even permit spatiotemporal programming of the properties of material surface,allowing multiplexed control over cellular and communal behaviors.1 It shall be noted that here the concept of“surface properties”encompasses a holistic collection of structures and properties,including topography(e.g.,static or dynamic),native and derived chemistry(e.g.,surface energy,surface charge,surfaceimmobilized ligands and proteins),and mechanical properties(e.g.,stiffness).

关 键 词：SYNTHETIC TOPOGRAPHY enable 

分 类 号：TG1[金属学及工艺—金属学]