MiR-429生物学功能的研究进展  

Advances in biological functions of miR-429

作　　者：郭建林[1,2] 王雪晴 徐存拴 GUO Jian-lin;WANG Xue-qing;XU Cun-shuan(College of Life Science,He’nan Normal University,He’nan Xinxiang 453007,China;State Key Laboratory Cultivation Base for Cell Differentiation Regulation,He’nan Normal University,He’nan Xinxiang 453007,China)

机构地区：[1]河南师范大学生命科学学院,河南新乡453007 [2]河南省-科技部共建细胞分化调控国家重点实验室培育基地,河南新乡453007

出　　处：《解剖学报》2022年第2期266-272,共7页Acta Anatomica Sinica

基　　金：河南省基础与前沿技术研究计划(162300410144);河南师范大学博士启动基金(QD14176)。

摘　　要：微小RNA(miRNA)是一类长度在22个核苷酸左右的内源性非编码单链RNA。这类RNA在细胞中发挥着重要的生物学功能,其中miR-429经大量研究证实,可以通过对不同靶基因的表达进行调控从而发挥抑制肿瘤发生和进展的重要作用,同时也能够在细胞分化和神经性疾病中发挥作用。我们对miR-429及其下游靶基因在细胞增殖、凋亡、迁移和侵袭中发挥的作用进行了概述。MicroRNAs(miRNAs, miR) are endogenous non-coding single-stranded RNAs with a length of about 22 nucleotides. These RNAs play an important biological function within cells, among which, miR-429 has been proved to play an important role in inhibiting tumor development and tumor progression as well as in cell differentiation and neurological diseases by regulating the expression of different target genes. In this paper, the role of miR-429 and its downstream targeted genes in cell proliferation, apoptosis, migration and invasion is summarized.

关 键 词：微小RNA-429 生物学功能 细胞增殖 细胞迁移 细胞侵袭 

分 类 号：Q752[生物学—分子生物学]