肝脏移植物抗宿主病的中医证治思路探析  

Analysis on TCM syndrome and treatment strategies for liver graft-versus-host disease

作　　者：吴顺杰 铁伊静 李海珍 曹佳成 蔡喜远 何佳玲 林梓 许晓军[2] WU Shun-jie;TIE Yi-jing;LI Hai-zhen;CAO Jia-cheng;CAI Xi-yuan;HE Jia-ling;LIN Zi;XU Xiao-jun(The Seventh Affiliated Hospital of Sun Yat-sen University,Shenzhen 510109,China)

机构地区：[1]中山大学附属第七医院,深圳510109 [2]中山大学附属第七医院血液内科

出　　处：《中华中医药杂志》2022年第3期1537-1540,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：深圳市基础研究自由探索项目(No.JCY20180307150614412);深圳市基础研究面上项目(No.JCYJ20190812093601675);广东省自然科学基金项目(No.2014A030313398);光明区卫生系统中医药科研项目(No.GM2019010005)。

摘　　要：肝脏是异基因造血干细胞移植术后移植物抗宿主病(GVHD)最常见的靶器官之一,Ⅲ度以上肝脏GVHD常危及生命,影响造血干细胞移植的疗效。目前西医治疗肝脏GVHD的措施作用有限,早期识别、及时治疗是控制肝脏GVHD的关键。文章拟从中医病因病机、辨治治疗、临证体会3个方面探讨肝脏GVHD的预防和治疗,为临床上控制肝脏GVHD提供一个可行的方法。The liver is one of the most common target organs for graft-versus-host disease(GVHD) after allogeneic hematopoietic stem cell transplantation(allo-HSCT). Liver GVHD above grade II is often life-threatening and affects the efficacy of hematopoietic stem cell transplantation. It is critical for doctors to diagnose and treat hepatic GVHD earlier, however there is no more effective therapy to treat severe hepatic GVHD than ever. This paper intends to discuss TCM etiology and pathogenesis, syndrome characteristics and treatment, and clinical experience, so as to provide a feasible method to control hepatic GVHD in clinic.

关 键 词：异基因造血干细胞移植 移植物抗宿主病 肝脏 中医药疗法 黄疸 

分 类 号：R259[医药卫生—中西医结合]