针灸在慢性疼痛治疗中对奖赏系统疼痛调控神经递质影响的研究进展  

Research progress on the effects of acupuncture and moxibustion on pain regulating neurotransmitters of reward system in the treatment of chronic pain

作　　者：唐洁 武平[1] 余泽云 罗云 陶偲钰 王旖旎 TANG Jie;WU Ping;YU Ze-yun;LUO Yun;TAO Si-yu;WANG Yi-ni(Acupuncture and Moxibustion College,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学针灸推拿学院,成都610075

出　　处：《中华中医药杂志》2022年第3期1570-1573,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81373738);四川省科技计划项目(No.2017JY0016)。

摘　　要：奖赏系统是存在于大脑中能产生快感和各种动机的特定区域,慢性疼痛会通过改变大脑相应脑区神经递质的释放而影响奖赏效应。针灸治疗慢性疼痛的奖赏效应在于它能激活大脑神经奖赏系统,促使相应脑区神经递质的释放发生变化。因此,文章拟将神经递质作为针灸治疗慢性疼痛的靶点,通过对慢性疼痛与奖赏系统的关系以及针灸对神经递质影响的研究现状进行综述,探讨疼痛调控神经递质在镇痛过程中的奖赏效应,以及针灸治疗慢性疼痛在神经奖赏系统可能的效应机制,为临床治疗慢性疼痛类疾病提供优势治疗方案。Reward system is a specific area of the brain that can produce pleasure and various motives, chronic pain will affect the reward effect by changing the release of neurotransmitters in the corresponding brain regions. The reward effect of acupuncture and moxibustion on chronic pain is that it can activate the brain neural reward system and promote the release of neurotransmitters in the corresponding brain regions. Therefore, this paper intends to take neurotransmitters as the target of acupuncture and moxibustion in the treatment of chronic pain. By summarizing the relationship between chronic pain and reward system and the research progress on the impact of acupuncture and moxibustion on neurotransmitters, this paper discusses the reward effect of pain regulating neurotransmitters in the process of analgesia and the possible effect mechanism of acupuncture and moxibustion in the reward system, so as to provide an advantageous treatment scheme for clinical treatment of chronic pain diseases.

关 键 词：奖赏效应 针灸 慢性疼痛 神经递质 镇痛 

分 类 号：R246[医药卫生—针灸推拿学]